A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population

Kind of evidence: Human trial 2020 · 50 people · responders among 110 people with acne who completed an 8-week adapalene/BPO induction phase · PMID 33150170
Measured outcome: Skin effect
Year: 2020
Who was studied: 50 responders among 110 people with acne who completed an 8-week adapalene/BPO induction phase
Sample size: 50
Measured outcome: In a double-blind, randomized, vehicle-controlled left-right facial study, a moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine and salicylic acid significantly reduced mean non-inflammatory, inflammatory and total lesion counts versus the vehicle moisturizer at week 12 during the maintenance phase after adapalene/benzoyl peroxide treatment.
Certainty: Moderate
Who was measured: Non-inflammatory, inflammatory and total lesion counts during a 12-week maintenance phase.
Study limits: The study is in the maintenance phase after drug-induced clearance.

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