PoreWise One finding · Human trial · 2017
Study title
Superiority of a vitamin B(12)-containing emollient compared to a standard emollient in the maintenance treatment of mild-to-moderate plaque psoriasis
- Kind of evidence
- Human trial 2017 · 24 people · patients with plaque psoriasis · PMID 29048238
- Measured outcome
- Skin effect
- Year
- 2017
- Who was studied
- 24 patients with plaque psoriasis
- Sample size
- 24
- Measured outcome
- In 24 people with mild-to-moderate plaque psoriasis, a vitamin B12-containing ointment reduced PASI by 87.6% from baseline at week 12 versus 23.1% with a standard glycerol-petrolatum emollient on the opposite side (p < 0.001).
- Certainty
- Low
- Who was measured
- Adults with plaque psoriasis in the maintenance phase, applying the ointment twice daily for 12 weeks in a randomised, single-blind, left-right paired design.
- Study limits
- Single centre, 24 participants, single-blind, localised left-right design in the maintenance phase; the mainstream high-quality evidence for psoriasis still comes from prescription drugs and biologics.
Where it comes from
- Superiority of a vitamin B(12)-containing emollient compared to a standard emollient in the maintenance treatment of mild-to-moderate plaque psoriasis
Published by International Journal of Immunopathology and Pharmacology (Del Duca E, et al.) · Last checked 2026-11-10
Skin concerns studied
Other findings on the same ingredient or concern
- Skin effectTreatment of localized psoriasis with a topical formulation of zinc pyrithione
In a randomized, double-blind trial of 60 people with localised psoriasis, a 0.25% zinc pyrithione cream reduced mean PASI from 3.4 to 0.9 over 3 months (p < 0.01) and was significantly better than the emollient base, which changed from 4.3 to 3.9 (p > 0.05).
Human trial · 2011 · 60 people · patients with localised psoriasis (30/30) · People with localised psoriasis affecting less than 10% of body surface area, applying the cream twice daily for 3 months. · Limited to localised, mild psoriasis; an over-the-counter active ingredient.