PoreWise

One finding · Human trial · 2025

Study title

Clinical Observation of a Novel Moisturizing Cream for Reducing Neurovascular Hyper-Reactivity in Sensitive Skin

Kind of evidence
Human trial 2025 · 35 people · people with sensitive skin · PMID 40736038
Measured outcome
Skin effect
Year
2025
Who was studied
35 people with sensitive skin
Sample size
35
Measured outcome
In a 28-day randomized, double-blind split-face trial of 35 people with sensitive skin, a moisturising cream outperformed a control cream in improving pruritus, erythema and transepidermal water loss, while both creams improved sensitive-skin symptoms and signs.
Certainty
Low
Who was measured
People with sensitive skin applying the creams twice daily for 28 days.
Study limits
A comparison against another active cream.

Where it comes from

PMID 40736038

Skin concerns studied

Other findings on the same ingredient or concern

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    Clinical and instrumental assessment of the effects of a new product based on hydroxypropyl chitosan and potassium azeloyl diglycinate in the management of rosacea

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    Human trial · 2012 · 42 people · adults with rosacea stage I-II · Facial erythema measured by Mexameter and clinical grading over 28 days. · Pilot sample; rosacea is a disease population.

    PMID 22360333

  2. Skin effect
    A Randomized, Controlled Clinical Trial of a Dermocosmetic Containing Vichy Volcanic Mineralizing Water and Probiotic Fractions in Subjects with Rosacea Associated with Erythema and Sensitive Skin and Wearing Protective Masks

    In a randomized split-face controlled trial in people with rosacea-associated erythema and sensitive skin, a dermocosmetic containing mineralizing water, probiotic fractions, hyaluronic acid and niacinamide significantly improved erythema at day 15 (p<0.01) and day 30 (p<0.001), with skin erythema, tightness, dryness, hydration and TEWL improving versus the untreated side (p<=0.05).

    Human trial · 2023 · People with rosacea-associated erythema and sensitive skin wearing protective masks · Facial erythema, tightness, dryness, hydration and TEWL over 30 days. · The comparator is usual skin care / an untreated half-face.

    PMID 36660190

  3. Skin effect
    Topical nicotinamide for seborrheic dermatitis: an open randomized study

    In an open randomized, vehicle-controlled trial of 48 people with mild-to-moderate facial seborrheic dermatitis, 4% nicotinamide cream once daily for 12 weeks reduced the combined erythema/scaling/infiltration score by 75% from baseline versus 35% with the vehicle (p<0.05).

    Human trial · 2014 · 48 people · people (36 men, 12 women) aged 20-50 with mild-to-moderate facial seborrheic dermatitis · Combined clinical score of erythema, scaling and infiltration over 12 weeks. · Open-label.

    PMID 23763270