Digital image analysis of the effect of topically applied linoleic acid on acne microcomedones

Kind of evidence: Human trial 1998 · People with mild acne · PMID 9692305
Measured outcome: Skin effect
Year: 1998
Who was studied: People with mild acne.
Sample size
Measured outcome: In a double-blind, placebo-controlled randomized cross-over study in people with mild acne, one month of topical linoleic acid reduced the overall size of follicular casts and microcomedones by almost 25% on digital image analysis of cyanoacrylate follicular biopsies.
Certainty: Moderate
Who was measured: Follicular casts and microcomedones on the face, measured by cyanoacrylate follicular biopsy.
Study limits: Demographics, or the concentration used; the endpoint is the size of casts. This study measures follicular plugs.

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