PoreWise Ingredient
Gluconolactone
Public databaseGLUCONOLACTONE
Gluconolactone is a cyclic lactone of gluconic acid, and a polyhydroxy acid. Its molecule is larger than glycolic acid, and it chelates metals too. The strongest evidence comes from a 1992 human trial: In a double-blind trial of 150 people with mild-to-moderate acne, a 14% gluconolactone solution and a 5% benzoyl peroxide lotion each reduced inflamed and non-inflamed lesion counts significantly more than the vehicle lotion, and fewer side-effects were reported with gluconolactone than with benzoyl peroxide. 1992 · 150 people · people with mild-to-moderate acne · PMID 1303072 · Confidence intervals or treatment duration. The trial is from 1992 and used a 14% leave-on solution. It compares gluconolactone with benzoyl peroxide and vehicle. 1 product contains Gluconolactone, at number 7 of 27 on its ingredient list.
- INCI name:
- GLUCONOLACTONE
- CAS number:
- 90-80-2
- Source:
- PubChem
Functions
Products with this ingredient
Gluconolactone appears on 1 product ingredient lists, most often around number 7; its highest position is number 7 of 27.
| Product | Brand | Where it sits on the list |
|---|---|---|
| Acne Control Cleanser | CeraVe | 7 of 27 |
Studies and results
- 1 Skin effectA comparative study of gluconolactone versus benzoyl peroxide in the treatment of acne
In a double-blind trial of 150 people with mild-to-moderate acne, a 14% gluconolactone solution and a 5% benzoyl peroxide lotion each reduced inflamed and non-inflamed lesion counts significantly more than the vehicle lotion, and fewer side-effects were reported with gluconolactone than with benzoyl peroxide.
Human trial · 1992 · 150 people · people with mild-to-moderate acne · Inflamed and non-inflamed acne lesion counts, and local side-effects, in mild-to-moderate acne. · Confidence intervals or treatment duration. The trial is from 1992 and used a 14% leave-on solution. It compares gluconolactone with benzoyl peroxide and vehicle.
Skin concerns this ingredient has been studied for
The people in each study had that concern.
Common questions
- What does Gluconolactone do in skincare?
- Gluconolactone is a cyclic lactone of gluconic acid, and a polyhydroxy acid. Its molecule is larger than glycolic acid, and it chelates metals too.
- Where does Gluconolactone sit in these formulas?
- Gluconolactone appears in 1 product, Acne Control Cleanser, at number 7 of 27 on its ingredient list.
- Which products contain Gluconolactone?
- Products that contain Gluconolactone: Acne Control Cleanser.
- How strong is the evidence behind Gluconolactone?
- Gluconolactone has one study behind it: a 1992 human trial of 150 people with mild-to-moderate acne.
- What did the study on Gluconolactone measure?
- 1992 · 150 people · people with mild-to-moderate acne · PMID 1303072 · Confidence intervals or treatment duration. The trial is from 1992 and used a 14% leave-on solution. It compares gluconolactone with benzoyl peroxide and vehicle.