Source · study A cream of herbal mixture to improve melasma Primary source Publisher:Journal of Cosmetic Dermatology (Zhang Q, Tu Y, Gu H, et al.) Source type:Journal · study Last checked:2026-10-29 URL: https://doi.org/10.1111/jocd.12938 Pages that cite it Evidence: In a randomized, double-blind, controlled study of 90 volunteers with melasma, the arbutin-cream arm showed a significant fall in melasma severity score from 12.65 to 10.84 over 12 weeks; two participants had mild erythema and itching that resolved after stopping the cream.