Source · study Improvement of naturally aged skin with vitamin A (retinol) Primary source Publisher:Archives of Dermatology (Kafi, Kwak, Schumacher et al.) Source type:Journal · study Last checked:2026-10-29 URL: https://doi.org/10.1001/archderm.143.5.606 Pages that cite it Evidence: A 0.4% retinol lotion applied to the arm up to three times a week for 24 weeks reduced fine wrinkling significantly more than its vehicle in elderly subjects: score change −1.64 (95% CI −2.06 to −1.22) against −0.08 (−0.17 to 0.01) on a 0–9 severity scale.