Source · study

Improvement of photoaged facial skin in middle-aged Japanese females by topical retinol (vitamin A alcohol): a vehicle-controlled, double-blind study

Primary source

Publisher:: Journal of Dermatological Treatment (Kikuchi, Suetake, Kumasaka & Tagami)
Source type:: Journal · study
Last checked:: 2026-10-29
URL:: https://doi.org/10.1080/09546630902973987

Pages that cite it

Evidence: Nightly 0.075% retinol caused enough irritation for 3 of 57 participants to withdraw from the study; at 0.04% over 13 weeks irritation was reported as minimal, with less improvement in fine wrinkling.
Evidence: In a split-face comparison, 0.075% retinol cream used once nightly for 26 weeks improved fine wrinkling in 27 of 54 participants (50%) against 13 (24%) on the vehicle side, and deep wrinkling in 15 (28%) against 1 (2%).