PoreWise One finding · Human trial · 2024
Study title
Assessing the Effectiveness of Stabilized Cysteamine 5% Cream Compared to Hydroquinone 4%/Ascorbic Acid 3% Combination Cream in Treating Acne-induced Post-inflammatory Hyperpigmentation: A Randomized, Controlled Study
- Kind of evidence
- Human trial 2024 · 28 people · enrolled, 28 completed, with acne-induced PIH · PMID 38638185
- Measured outcome
- Skin effect
- Year
- 2024
- Who was studied
- 32 enrolled, 28 completed, with acne-induced PIH
- Sample size
- 28
- Measured outcome
- In 28 people with acne-induced post-inflammatory hyperpigmentation, both a 5% stabilised cysteamine cream and a 4% hydroquinone/3% ascorbic acid cream significantly reduced PAHPI scores and melanin index over 4 months, with similar values between treatments.
- Certainty
- Moderate
- Who was measured
- People with acne-induced post-inflammatory hyperpigmentation, treated for 4 months.
- Study limits
- The comparison treatment contains hydroquinone, a drug ingredient; small sample (28 completed).
Where it comes from
- Assessing the Effectiveness of Stabilized Cysteamine 5% Cream Compared to Hydroquinone 4%/Ascorbic Acid 3% Combination Cream in Treating Acne-induced Post-inflammatory Hyperpigmentation: A Randomized, Controlled Study
Published by Journal of Clinical and Aesthetic Dermatology (Ahmadi K, et al.) · Last checked 2026-11-10
Skin concerns studied
Other findings on the same ingredient or concern
- Skin effectEffects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris
In 72 people with mild-to-moderate acne, a 15% azelaic acid gel reduced post-inflammatory erythema (PAHPI) significantly more than placebo at weeks 8 and 12, and lowered melanin content in post-inflammatory hyperpigmentation lesions at week 12.
Human trial · 2024 · 72 people · patients with mild-to-moderate acne (60 completed) · People with mild-to-moderate acne and acne-induced post-inflammatory erythema or hyperpigmentation, applying the gel twice daily for 12 weeks. · PIH lesion counts improved from baseline in both groups; the significant between-group difference was in PAHPI and melanin content.