PoreWise One finding · Human trial · 2024
Study title
Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris
- Kind of evidence
- Human trial 2024 · 72 people · patients with mild-to-moderate acne (60 completed) · PMID 38734843
- Measured outcome
- Skin effect
- Year
- 2024
- Who was studied
- 72 patients with mild-to-moderate acne (60 completed)
- Sample size
- 72
- Measured outcome
- In 72 people with mild-to-moderate acne, a 15% azelaic acid gel reduced post-inflammatory erythema (PAHPI) significantly more than placebo at weeks 8 and 12, and lowered melanin content in post-inflammatory hyperpigmentation lesions at week 12.
- Certainty
- High
- Who was measured
- People with mild-to-moderate acne and acne-induced post-inflammatory erythema or hyperpigmentation, applying the gel twice daily for 12 weeks.
- Study limits
- PIH lesion counts improved from baseline in both groups; the significant between-group difference was in PAHPI and melanin content.
Where it comes from
- Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris
Published by Dermatology and Therapy (Shucheng H, et al.) · Last checked 2026-11-10
Ingredients it was measured on
Skin concerns studied
Other findings on the same ingredient or concern
- Skin effectEfficacy and safety of a novel anhydrous 0.1% retinal and 10% azelaic acid concentrate for blemish-prone skin: an eight-week randomized prospective split-face, vehicle-controlled study
In an 8-week randomized, vehicle-controlled split-face study of 23 people with blemish-prone skin, an anhydrous 0.1% retinal / 10% azelaic acid concentrate improved the pore parameter by 22.3% versus vehicle (p=0.015) and skin texture by 5.6% versus vehicle (p=0.0016), and reduced surface irregularities by 12.7% versus vehicle (p=0.0053).
Human trial · 2026 · 23 people · participants aged 16-49 (mean 28), Fitzpatrick I-IV, blemish-prone skin · Pore appearance, skin texture and surface irregularities on the face over 8 weeks. · The pore improvement versus baseline was borderline (15.9%, p=0.051); the small sample completed 23 participants; the product is a six-ingredient concentrate; 10% azelaic acid is regulated as an OTC drug in some markets.
- Skin effectAssessing the Effectiveness of Stabilized Cysteamine 5% Cream Compared to Hydroquinone 4%/Ascorbic Acid 3% Combination Cream in Treating Acne-induced Post-inflammatory Hyperpigmentation: A Randomized, Controlled Study
In 28 people with acne-induced post-inflammatory hyperpigmentation, both a 5% stabilised cysteamine cream and a 4% hydroquinone/3% ascorbic acid cream significantly reduced PAHPI scores and melanin index over 4 months, with similar values between treatments.
Human trial · 2024 · 28 people · enrolled, 28 completed, with acne-induced PIH · People with acne-induced post-inflammatory hyperpigmentation, treated for 4 months. · The comparison treatment contains hydroquinone, a drug ingredient; small sample (28 completed).