PoreWise One finding · Human trial · 2026
Study title
Efficacy and safety of a novel anhydrous 0.1% retinal and 10% azelaic acid concentrate for blemish-prone skin: an eight-week randomized prospective split-face, vehicle-controlled study
- Kind of evidence
- Human trial 2026 · 23 people · participants aged 16-49 (mean 28), Fitzpatrick I-IV, blemish-prone skin · PMID 42572367
- Measured outcome
- Skin effect
- Year
- 2026
- Who was studied
- 23 participants aged 16-49 (mean 28), Fitzpatrick I-IV, blemish-prone skin
- Sample size
- 23
- Measured outcome
- In an 8-week randomized, vehicle-controlled split-face study of 23 people with blemish-prone skin, an anhydrous 0.1% retinal / 10% azelaic acid concentrate improved the pore parameter by 22.3% versus vehicle (p=0.015) and skin texture by 5.6% versus vehicle (p=0.0016), and reduced surface irregularities by 12.7% versus vehicle (p=0.0053).
- Certainty
- Moderate
- Who was measured
- Pore appearance, skin texture and surface irregularities on the face over 8 weeks.
- Study limits
- The pore improvement versus baseline was borderline (15.9%, p=0.051); the small sample completed 23 participants; the product is a six-ingredient concentrate; 10% azelaic acid is regulated as an OTC drug in some markets.
Where it comes from
- Efficacy and safety of a novel anhydrous 0.1% retinal and 10% azelaic acid concentrate for blemish-prone skin: an eight-week randomized prospective split-face, vehicle-controlled study
Published by International Journal of Cosmetic Science (Gaudicheau C, 2026) · Last checked 2026-11-10
Ingredients it was measured on
Skin concerns studied
Other findings on the same ingredient or concern
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Human trial · 2015 · 80 people · subjects aged 12+ with mild-to-moderate acne · Closed-comedone and inflammatory lesion counts over 12 weeks. · The comparator is an active benzoyl peroxide regimen.
- Skin effectEvaluation of anti-wrinkle effects of a novel cosmetic containing niacinamide
In a randomized, placebo-controlled split-face study of 30 healthy Japanese women, a cosmetic containing 4% niacinamide reduced the skin-surface average roughness (Ra) value significantly more than the niacinamide-free control site after 8 weeks (P<0.05).
Human trial · 2008 · 30 people · healthy Japanese women with wrinkles in the eye areas · Skin-surface roughness measured by replica profilometry (Ra). · Measured at the eye area on a photoaged/wrinkle cohort; the endpoint is surface roughness.
- Skin effectThe effect of physically applied alpha hydroxyl acids on the skin pore and comedone
In 23 women, a single application of a 4% alpha-hydroxy acid solution combined with negative-pressure physical action significantly reduced whitehead and blackhead counts at 1, 2 and 4 weeks, and reduced pore area and number at week 1, compared with AHA peeling alone.
Human trial · 2015 · 23 people · healthy women (mean age 30) · Healthy women receiving a single in-clinic application in a randomised split-face design, assessed at 1, 2 and 4 weeks. · The intervention was a single in-clinic chemical peeling plus negative-pressure physical action.
- Skin effectEfficacy and safety of a facial serum and a mask containing salicylic acid and lipohydroxy acid in acne management: A randomized controlled trial
In 83 adults with comedones, a serum containing salicylic acid and lipohydroxy acid significantly improved open comedones on the nose, closed comedones on the face, skin pore density, sebum secretion and skin hydration from baseline after 8 weeks; adding a mask improved closed comedones more than the serum alone (-6.56 vs -5.19, p = 0.022).
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