One finding · Human trial · 2022
Study title
Effects of a grapeseed oil (Vitis vinifera L.) loaded dermocosmetic nanoemulgel on biophysical parameters of facial skin: A split-face, blinded, placebo-controlled study
- Kind of evidence
- Human trial 2022 · 15 people · healthy volunteers · PMID 35713012
- Measured outcome
- Skin effect
- Year
- 2022
- Who was studied
- 15 healthy volunteers.
- Sample size
- 15
- Measured outcome
- In a split-face, blinded, placebo-controlled study of 15 volunteers, a grapeseed-oil nanoemulgel applied for 12 weeks significantly reduced facial sebum production and fine and large pores while significantly increasing skin moisture content and elasticity versus placebo (all p<0.05).
- Certainty
- Low
- Who was measured
- Facial sebum, pore appearance, skin moisture and elasticity over 12 weeks.
- Study limits
- Very small sample; measurements were taken on the cheeks/half-face.
Where it comes from
- Effects of a grapeseed oil (Vitis vinifera L.) loaded dermocosmetic nanoemulgel on biophysical parameters of facial skin: A split-face, blinded, placebo-controlled study
Published by Journal of Cosmetic Dermatology (Shawahna R, 2022) · Last checked 2026-11-10
Ingredients it was measured on
Skin concerns studied
Other findings on the same ingredient or concern
- Skin effectClinical Efficacy of a Salicylic Acid-Containing Gel on Acne Management and Skin Barrier Function: A 21-Day Prospective Study
In a 21-day prospective study of 42 people with mild-to-moderate acne and oily or combination skin, a salicylic-acid-containing gel used twice daily was associated with a 23.65% fall in sebum, a 40.5% rise in skin hydration, a 49.26% fall in transepidermal water loss and a 23.81% improvement in acne grade (all P < 0.05 except IGA P < 0.001).
Human trial · 2025 · 42 people · people (37 women, 5 men) with mild-to-moderate acne and oily or combination skin, mean age 25.9 · Sebum, skin hydration, transepidermal water loss and acne grade over 21 days in people with oily or combination skin. · One centre, 21 days, 37 of 42 participants were women, and the research group was affiliated with the product maker.
- OtherThe Effect of Microneedling Mesotherapy, Chemical Exfoliation and Combination Therapy on Selected Skin Parameters and Cutibacterium acnes Colonization in Women With Oily Skin
In a randomized study of 55 women with oily skin, sebum, hydration and pH were measured separately on the cheeks and in the T-zone before and after six in-clinic sessions. Microneedling lowered T-zone sebum after all six sessions, mandelic-acid peeling lowered it mainly on the cheeks, and the combined protocol lowered it in both areas.
Human trial · 2026 · 55 people · women aged 18-47 with oily skin · Separate cheek and T-zone readings of sebum, hydration and pH across six in-clinic sessions. · The treatments were in-clinic microneedling and chemical peeling. All 55 participants had oily skin.
- Skin effectThe safety and efficacy of 3% Cannabis seeds extract cream for reduction of human cheek skin sebum and erythema content
In a 12-week single-blind, base-controlled study in healthy men, a cream containing 3% Cannabis seed extract significantly reduced cheek sebum and erythema compared with the extract-free base (p<0.05).
Human trial · 2015 · Healthy men · Cheek sebum (Sebumeter) and erythema (Mexameter) over 12 weeks. · The study is single-blind comparative.
- Skin effectEfficacy of anti-sebum moisturizing cream containing 2% l-carnitine and 5% epigallocatechin gallate in seborrhea: A randomized clinical trial
In 90 people with seborrhea, moisturisers containing 2% L-carnitine, 5% epigallocatechin gallate, or both produced statistically significant reductions in sebum level from baseline over 4 weeks, with the EGCG and combination groups showing greater anti-sebum effects than L-carnitine alone (p = 0.009).
Human trial · 2023 · 90 people · subjects with seborrhea · People with seborrhea applying an anti-sebum moisturising cream for 4 weeks. · All three arms contained active ingredients; sebum was measured alongside hydration and TEWL improvements.
- Skin effectThe effect of 2% niacinamide on facial sebum production
In a double-blind, placebo-controlled trial of 100 Japanese subjects, a 2% niacinamide moisturiser significantly lowered sebum excretion rate after 2 and 4 weeks; in a separate 30-person Caucasian split-face study it significantly reduced casual sebum level after 6 weeks.
Human trial · 2006 · 100 people · Japanese subjects plus 30 Caucasian subjects · Adults with facial sebum concerns applying a 2% niacinamide moisturiser for 2 to 6 weeks; measured with sebumeter-based sebum excretion rate and casual sebum level. · The effect differs by measured endpoint and population.