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One finding · Human trial · 2024

Study title

Successful treatment of solar lentigines by topical application of stabilized cysteamine: A vehicle-controlled, double-blind randomized study

Kind of evidence
Human trial 2024 · 30 people · people with solar lentigines · PMID 38410492
Measured outcome
Skin effect
Year
2024
Who was studied
30 people with solar lentigines
Sample size
30
Measured outcome
In 30 people with solar lentigines, a stabilised cysteamine cream reduced colourimetric values by 40% and VAS scores by 40% over 12 weeks, versus 2% for both with the vehicle cream.
Certainty
Moderate
Who was measured
People with solar lentigines on the hands, applying the cream once daily for 12 weeks.
Study limits
Small sample (30), lesions on the hands.

Where it comes from

PMID 38410492

Skin concerns studied

Other findings on the same ingredient or concern

  1. Skin effect
    A double-blind, placebo-controlled randomized trial of Serratulae quinquefoliae folium, a new source of beta-arbutin, in selected skin hyperpigmentations

    In a randomized, placebo-controlled, double-blind trial of 102 women with melasma or solar lentigo, a cream with 2.51% arbutin applied twice daily for 8 weeks lightened discolouration in 75.86% of the melasma group and 56.00% of the solar-lentigo group.

    Human trial · 2015 · 102 people · women (54 study / 48 control) with melasma or solar lentigo · Women aged 26-55 with melasma or solar lentigo, applying a 2.51% arbutin cream twice daily for 8 weeks. · The active was an aqueous extract standardised to 2.51% arbutin.

    PMID 26119285

  2. Skin effect
    A randomized controlled study to evaluate the depigmenting activity of L-ascorbic acid plus phytic acid-serum vs. placebo on solar lentigines

    In a double-blind, vehicle-controlled trial of 30 people with two or more solar lentigines, a serum with 10% L-ascorbic acid and 2% phytic acid lowered the pigmentation index of the treated lesions over three months while the vehicle-treated lesions stayed stable (P <= 0.003 from month 1 to month 4). Six adverse events, mostly halo depigmentation, were judged possibly related to the product.

    Human trial · 2011 · 30 people · healthy subjects with two or more solar lentigines · Pigmentation index, dermoscopic pigmentation and brightness (L*) of solar lentigines over three months, with two months of follow-up. · The serum combines two actives. Each person applied the product to one side of the body and the vehicle to the other. 30 people, and six halo-depigmentation events were possibly related to the product. The authors call for larger studies.

    PMID 22151934

  3. Skin effect
    Efficacy of D-pigment dermocosmetic lightening product for solar lentigo lesions of the hand: A randomized controlled trial

    In 36 people with solar lentigo lesions on the hands, a dermocosmetic lightening product improved papillary brightness, contrast, luminance and redness significantly more than a moisturising control over 12 months.

    Human trial · 2019 · 36 people · subjects, 72 solar lentigo lesions on the hands · Adults with solar lentigo lesions on the hands, followed for 12 months. · Lesions were on the hands.

    PMID 31042723

  4. Skin effect
    Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing

    In a 12-week randomized, double-blind trial of 44 people, both 0.5% bakuchiol and 0.5% retinol significantly reduced wrinkle surface area and hyperpigmentation; bakuchiol caused less scaling and stinging.

    Human trial · 2019 · 44 people · adults with facial photoageing · Adults with facial photoageing using bakuchiol twice daily or retinol once daily for 12 weeks. · Small sample (44).

    PMID 29947134

  5. Skin effect
    Efficacy and Tolerability of Topical 0.1% Stabilized Bioactive Retinol for Photoaging: A Vehicle-Controlled Integrated Analysis

    Across six vehicle-controlled studies pooled together (237 on retinol, 234 on vehicle), 0.1% stabilised retinol produced greater improvements from baseline in all signs of photoaging than the vehicle from week 4 through week 12.

    Human trial · 2024 · 471 people · participants across six vehicle-controlled studies · Women around 47 years old with mild-to-moderate photoaging, applying the product for 12 weeks. · Pooled analysis of six studies.

    PMID 38564380