PoreWise One finding · Human trial · 2011
Study title
A randomized controlled study to evaluate the depigmenting activity of L-ascorbic acid plus phytic acid-serum vs. placebo on solar lentigines
- Kind of evidence
- Human trial 2011 · 30 people · healthy subjects with two or more solar lentigines · PMID 22151934
- Measured outcome
- Skin effect
- Year
- 2011
- Who was studied
- 30 healthy subjects with two or more solar lentigines.
- Sample size
- 30
- Measured outcome
- In a double-blind, vehicle-controlled trial of 30 people with two or more solar lentigines, a serum with 10% L-ascorbic acid and 2% phytic acid lowered the pigmentation index of the treated lesions over three months while the vehicle-treated lesions stayed stable (P <= 0.003 from month 1 to month 4). Six adverse events, mostly halo depigmentation, were judged possibly related to the product.
- Certainty
- Moderate
- Who was measured
- Pigmentation index, dermoscopic pigmentation and brightness (L*) of solar lentigines over three months, with two months of follow-up.
- Study limits
- The serum combines two actives. Each person applied the product to one side of the body and the vehicle to the other. 30 people, and six halo-depigmentation events were possibly related to the product. The authors call for larger studies.
Where it comes from
- A randomized controlled study to evaluate the depigmenting activity of L-ascorbic acid plus phytic acid-serum vs. placebo on solar lentigines
Published by Journal of Cosmetic Dermatology (Khemis A, et al.) · Last checked 2026-11-11
Ingredients it was measured on
Skin concerns studied
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