PoreWise One finding · Human trial · 2024
Study title
Functional properties and skin care effects of sodium trehalose sulfate
- Kind of evidence
- Human trial 2024 · 26 people · Japanese women aged 33-59 with low stratum corneum water content, high water evaporation and low surface lipids · PMID 38606717
- Measured outcome
- Skin effect
- Year
- 2024
- Who was studied
- 26 Japanese women aged 33-59 with low stratum corneum water content, high water evaporation and low surface lipids
- Sample size
- 26
- Measured outcome
- In a randomized, double-blind, placebo-controlled study of 26 women selected for low stratum corneum water content, applying a lotion and emulsion containing 0.05% sodium trehalose sulfate to the face for 4 weeks decreased transepidermal water loss and increased stratum corneum water content versus the active-free placebo.
- Certainty
- Moderate
- Who was measured
- Facial TEWL and stratum corneum water content over 4 weeks.
- Study limits
- Small sample (13 per group); part of the paper reports in-vitro 3D epidermal model work, which is separate from the human trial; company-affiliated research.
Where it comes from
- Functional properties and skin care effects of sodium trehalose sulfate
Published by Skin Research and Technology (Maeda K, 2024) · Last checked 2026-11-10
Skin concerns studied
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