PoreWise One finding · Human trial · 2025
Study title
Efficacy of Pseudo-Ceramide Absorption Into the Stratum Corneum and Effects on Transepidermal Water Loss and the Ceramide Profile: A Randomized Controlled Trial
- Kind of evidence
- Human trial 2025 · 54 people · Japanese women aged 20-49 with self-perceived dry sensitive skin and cheek TEWL >10 g/m2 per hour · PMID 39492723
- Measured outcome
- Skin effect
- Year
- 2025
- Who was studied
- 54 Japanese women aged 20-49 with self-perceived dry sensitive skin and cheek TEWL >10 g/m2 per hour
- Sample size
- 54
- Measured outcome
- In a randomized, single-blind controlled trial of 54 Japanese women with dry, sensitive facial skin, 4 weeks of a pseudo-ceramide-containing facial spray improved scaling score, stratum corneum water content, TEWL and corneocyte area, while a commercially available spray.
- Certainty
- Moderate
- Who was measured
- Facial scaling score, stratum corneum water content and TEWL over 4 weeks.
- Study limits
- Single-blind; the comparator is a commercial spray.
Where it comes from
- Efficacy of Pseudo-Ceramide Absorption Into the Stratum Corneum and Effects on Transepidermal Water Loss and the Ceramide Profile: A Randomized Controlled Trial
Published by Journal of Cosmetic Dermatology (Akahane T, 2025) · Last checked 2026-11-10
Skin concerns studied
Other findings on the same ingredient or concern
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Human trial · 2026 · 25 people · young Chinese women with sensitive skin · Facial skin hydration, redness and wrinkles over 4 weeks. · Skin microbiome diversity showed similar change; the study has a company background.
- Skin effectCombined effects of glycerol and petrolatum in an emollient cream: A randomized, double-blind, crossover study in healthy volunteers with dry skin
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Human trial · 2020 · 51 people · healthy volunteers with dry skin (Kligman score 2 or 3) · Corneometry (skin moisture) and transepidermal water loss over 12 hours after one application. · Measured on the forearms. The significant hydration result comes from the full emollient containing both glycerol and petrolatum.
- Skin effectFunctional properties and skin care effects of sodium trehalose sulfate
In a randomized, double-blind, placebo-controlled study of 26 women selected for low stratum corneum water content, applying a lotion and emulsion containing 0.05% sodium trehalose sulfate to the face for 4 weeks decreased transepidermal water loss and increased stratum corneum water content versus the active-free placebo.
Human trial · 2024 · 26 people · Japanese women aged 33-59 with low stratum corneum water content, high water evaporation and low surface lipids · Facial TEWL and stratum corneum water content over 4 weeks. · Small sample (13 per group); part of the paper reports in-vitro 3D epidermal model work, which is separate from the human trial; company-affiliated research.
- Skin effectGlycerol and the skin: holistic approach to its origin and functions
Topical glycerol improves stratum corneum hydration, barrier function and skin mechanical properties. The review also reports reduced irritation response and faster wound healing, and traces the effect to aquaporin-3 transport and to glycerol's own presence in the skin.
Review article · 2008 · Humans in the cited studies, plus animal and in-vitro work on mechanism · Leave-on products. The review discusses both healthy skin and skin with dry or barrier-impaired conditions such as atopic dermatitis. · A narrative review. It compiles mechanisms and results from other studies.
- Skin effectEfficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment
All five 0.1% hyaluronic acid creams tested, from 50 kDa to 2000 kDa, raised skin hydration and overall elasticity above the vehicle cream applied to the other eye at 60 days.
Human trial · 2011 · 76 people · Women aged 30-60 with periocular wrinkles · 0.1% hyaluronic acid creams applied twice daily for 60 days to the eye area of women aged 30-60 with periocular wrinkles. · Sixty days, and the vehicle sat on the fellow eye. Hydration and elasticity were read by instruments. The volunteers were women aged 30-60 with eye-area wrinkles.