PoreWise One finding · Animal study · 2007
Study title
Comedogenicity in rabbit: some cosmetic ingredients/vehicles
- Kind of evidence
- Animal study 2007 · Rabbits (external ear canal) · PMID 18058303
- Measured outcome
- Pore clogging
- Year
- 2007
- Who was studied
- Rabbits (external ear canal)
- Sample size
- Measured outcome
- In the rabbit ear-canal assay, the nine materials graded positive were eight esters (isopropyl palmitate, isopropyl myristate, butyl stearate, isopropyl isostearate, decyl oleate, isostearyl neopentanoate, isocetyl stearate, myristyl myristate) and cocoa butter.
- Certainty
- Low
- Who was measured
- Materials applied to the rabbit ear canal as raw ingredients.
- Study limits
- An animal assay. The rabbit ear canal reacts more readily than human skin. The abstract names the positive group.
Where it comes from
- Comedogenicity in rabbit: some cosmetic ingredients/vehicles
Published by Cutaneous and Ocular Toxicology (Nguyen, Dang & Maibach) · Last checked 2026-10-26
Ingredients it was measured on
Other findings on the same ingredient or concern
- IrritationFinal Report on the Safety Assessment of Stearyl Alcohol, Oleyl Alcohol, and Octyl Dodecanol
The CIR expert panel's 1985 assessment of stearyl alcohol reports minimal to mild cutaneous irritation in rabbit tests, and a very low order of irritation and sensitization in clinical patch testing. It concluded that stearyl alcohol is safe as used in cosmetics.
Review article · 1985 · People using cosmetics containing stearyl alcohol; clinical patch-test subjects · Stearyl alcohol, one of the two fatty alcohols that cetearyl alcohol is made of, at the use concentrations reported to the panel. · It assesses stearyl alcohol. It was published in 1985 and relies largely on data submitted by the ingredient trade association. "Very low order" is the panel's wording.