PoreWise One finding · Review article · 1985
Study title
Final Report on the Safety Assessment of Stearyl Alcohol, Oleyl Alcohol, and Octyl Dodecanol
- Kind of evidence
- Review article 1985 · People using cosmetics containing stearyl alcohol; clinical patch-test subjects · DOI 10.3109/10915818509078685
- Measured outcome
- Irritation
- Year
- 1985
- Who was studied
- People using cosmetics containing stearyl alcohol; clinical patch-test subjects
- Sample size
- Measured outcome
- The CIR expert panel's 1985 assessment of stearyl alcohol reports minimal to mild cutaneous irritation in rabbit tests, and a very low order of irritation and sensitization in clinical patch testing. It concluded that stearyl alcohol is safe as used in cosmetics.
- Certainty
- Low
- Who was measured
- Stearyl alcohol, one of the two fatty alcohols that cetearyl alcohol is made of, at the use concentrations reported to the panel.
- Study limits
- It assesses stearyl alcohol. It was published in 1985 and relies largely on data submitted by the ingredient trade association. "Very low order" is the panel's wording.
Where it comes from
- Final Report on the Safety Assessment of Stearyl Alcohol, Oleyl Alcohol, and Octyl Dodecanol
Published by Cosmetic Ingredient Review Expert Panel (International Journal of Toxicology, vol. 4 no. 5) · Last checked 2026-10-26
Ingredients it was measured on
Skin concerns studied
Other findings on the same ingredient or concern
- Pore cloggingComedogenicity in rabbit: some cosmetic ingredients/vehicles
In the rabbit ear-canal assay, the nine materials graded positive were eight esters (isopropyl palmitate, isopropyl myristate, butyl stearate, isopropyl isostearate, decyl oleate, isostearyl neopentanoate, isocetyl stearate, myristyl myristate) and cocoa butter.
Animal study · 2007 · Rabbits (external ear canal) · Materials applied to the rabbit ear canal as raw ingredients. · An animal assay. The rabbit ear canal reacts more readily than human skin. The abstract names the positive group.
- Skin effectThe Effectiveness and Safety of a Skin Care Product With Centella asiatica Leaf Extract, Ceramide NP, and Panthenol in Subjects With Sensitive Skin: A Prospective, Observational Study
In 88 women with sensitive skin, a face cream containing Centella asiatica leaf extract, ceramide NP and panthenol lowered the SS-10 symptom score by 66% at week 2 and 76% at week 4, with irritation, tautness, itching and redness all significantly reduced.
Human trial · 2025 · 88 people · women with sensitive skin · Chinese women with sensitive skin applying the cream to the whole face, followed up at day 2, weeks 1, 2 and 4. · Observational and self-controlled.
- Skin effectMonocentric, Vehicle-Controlled, Double-Blind Study to Assess the Short- and Long-Term Effects of a Ceramide NP C15-Containing Emollient on the Skin Microbiome and the Skin Barrier Function in Sensitive Skin
In a randomized, double-blind, vehicle-controlled split-body trial of 50 people with sensitive skin, an emollient containing Ceramide NP C15 significantly reduced transepidermal water loss in participants with an impaired skin barrier over 6 weeks.
Human trial · 2026 · 50 people · people with sensitive skin · People with sensitive skin applying the emollient in a split-body design for 6 weeks; the barrier improvement was clearest in those whose barrier was already impaired. · Exploratory; both the ceramide formulation and the vehicle improved subjective symptoms, and the significant TEWL reduction was seen specifically in the impaired-barrier subgroup.
- Skin effectNiacinamide-containing facial moisturizer improves skin barrier and benefits subjects with rosacea
A facial moisturiser containing niacinamide improved stratum corneum barrier function and skin hydration, measured instrumentally, in people with rosacea over four weeks of twice-daily use.
Human trial · 2005 · 50 people · Adults with rosacea · A leave-on facial moisturiser, applied twice daily for four weeks, in adults with rosacea. · The tested article was a finished moisturiser. Fifty participants, one centre, four weeks. The study measured barrier function and hydration.
- Skin effectEfficacy and safety of a cream containing panthenol, prebiotics, and probiotic lysate for improving sensitive skin symptoms
In 110 people with facial sensitive skin, a cream containing panthenol used twice daily for 28 days significantly increased stratum corneum moisture and reduced erythema index, redness (a* value) and transepidermal water loss.
Human trial · 2024 · 110 people · people with facial sensitive skin · People with facial sensitive skin applying the cream twice daily for 28 days. · Panthenol was combined with prebiotics and a probiotic lysate.