PoreWise One finding · Human trial · 2025
Study title
The Effectiveness and Safety of a Skin Care Product With Centella asiatica Leaf Extract, Ceramide NP, and Panthenol in Subjects With Sensitive Skin: A Prospective, Observational Study
- Kind of evidence
- Human trial 2025 · 88 people · women with sensitive skin · PMID 40682399
- Measured outcome
- Skin effect
- Year
- 2025
- Who was studied
- 88 women with sensitive skin
- Sample size
- 88
- Measured outcome
- In 88 women with sensitive skin, a face cream containing Centella asiatica leaf extract, ceramide NP and panthenol lowered the SS-10 symptom score by 66% at week 2 and 76% at week 4, with irritation, tautness, itching and redness all significantly reduced.
- Certainty
- Moderate
- Who was measured
- Chinese women with sensitive skin applying the cream to the whole face, followed up at day 2, weeks 1, 2 and 4.
- Study limits
- Observational and self-controlled.
Where it comes from
- The Effectiveness and Safety of a Skin Care Product With Centella asiatica Leaf Extract, Ceramide NP, and Panthenol in Subjects With Sensitive Skin: A Prospective, Observational Study
Published by Journal of Cosmetic Dermatology (Su Z, Zheng Y, Yi J, Lai W, Ye C) · Last checked 2026-11-10
Ingredients it was measured on
Skin concerns studied
Other findings on the same ingredient or concern
- Skin effectMonocentric, Vehicle-Controlled, Double-Blind Study to Assess the Short- and Long-Term Effects of a Ceramide NP C15-Containing Emollient on the Skin Microbiome and the Skin Barrier Function in Sensitive Skin
In a randomized, double-blind, vehicle-controlled split-body trial of 50 people with sensitive skin, an emollient containing Ceramide NP C15 significantly reduced transepidermal water loss in participants with an impaired skin barrier over 6 weeks.
Human trial · 2026 · 50 people · people with sensitive skin · People with sensitive skin applying the emollient in a split-body design for 6 weeks; the barrier improvement was clearest in those whose barrier was already impaired. · Exploratory; both the ceramide formulation and the vehicle improved subjective symptoms, and the significant TEWL reduction was seen specifically in the impaired-barrier subgroup.
- Skin effectEfficacy and safety of a cream containing panthenol, prebiotics, and probiotic lysate for improving sensitive skin symptoms
In 110 people with facial sensitive skin, a cream containing panthenol used twice daily for 28 days significantly increased stratum corneum moisture and reduced erythema index, redness (a* value) and transepidermal water loss.
Human trial · 2024 · 110 people · people with facial sensitive skin · People with facial sensitive skin applying the cream twice daily for 28 days. · Panthenol was combined with prebiotics and a probiotic lysate.
- SensitizationPantothenic Acid as an Unexpected Cause of Hypersensitivity to Sensitive or Atopic Skin Care Products - A Narrative Review
Panthenol is treated as non-allergenic, this review argues that frequent exposure, especially on damaged skin, can produce hypersensitivity to it. The likely route is a delayed (type IV) contact reaction; immediate and mixed reactions remain possible. Proposes patch testing with the patient's own product and with panthenol 5% in petrolatum.
Review article · 2026 · People with atopic or damaged skin using panthenol-containing products · People who use panthenol products repeatedly, particularly those with atopic or damaged skin - the group the author says is most exposed. · A single-author narrative review. The mechanism it proposes is stated as likely. Read it as a reason to keep panthenol on the list of possible allergens.
- Skin effectTopical Application of Centella asiatica in Wound Healing: Recent Insights into Mechanisms and Clinical Efficacy
A 2024 review summarises that Centella asiatica's active compounds (asiaticoside, madecassoside, asiatic acid, madecassic acid) support collagen synthesis, moderate inflammation and provide antioxidant protection, and that clinical studies have explored topical Centella asiatica for wound healing and skin recovery.
Review article · 2024 · Topical Centella asiatica extracts and their isolated compounds. · This is a review.
- Skin effectMoisturizer Containing Centella Asiatica Extract, Ceramide NP, and Panthenol for Erythema and Skin Barrier in Erythematotelangiectatic Rosacea: A Randomized Controlled Trial
In a randomized controlled trial of 75 patients with erythematotelangiectatic rosacea, a moisturizer containing Centella asiatica extract, ceramide NP and panthenol produced greater improvements in facial redness and barrier measures than the control group at day 28.
Human trial · 2026 · 75 people · patients with erythematotelangiectatic rosasma · Adults with erythematotelangiectatic rosacea using the combination moisturizer twice daily for 28 days, alongside oral minocycline. · Centella asiatica was one of three actives in the moisturizer; all adverse events were mild and self-limiting.