PoreWise One finding · Human trial · 2026
Study title
Monocentric, Vehicle-Controlled, Double-Blind Study to Assess the Short- and Long-Term Effects of a Ceramide NP C15-Containing Emollient on the Skin Microbiome and the Skin Barrier Function in Sensitive Skin
- Kind of evidence
- Human trial 2026 · 50 people · people with sensitive skin · PMID 41758783
- Measured outcome
- Skin effect
- Year
- 2026
- Who was studied
- 50 people with sensitive skin
- Sample size
- 50
- Measured outcome
- In a randomized, double-blind, vehicle-controlled split-body trial of 50 people with sensitive skin, an emollient containing Ceramide NP C15 significantly reduced transepidermal water loss in participants with an impaired skin barrier over 6 weeks.
- Certainty
- Moderate
- Who was measured
- People with sensitive skin applying the emollient in a split-body design for 6 weeks; the barrier improvement was clearest in those whose barrier was already impaired.
- Study limits
- Exploratory; both the ceramide formulation and the vehicle improved subjective symptoms, and the significant TEWL reduction was seen specifically in the impaired-barrier subgroup.
Where it comes from
- Monocentric, Vehicle-Controlled, Double-Blind Study to Assess the Short- and Long-Term Effects of a Ceramide NP C15-Containing Emollient on the Skin Microbiome and the Skin Barrier Function in Sensitive Skin
Published by Skin Pharmacology and Physiology (Dimmers F, Krutmann J, et al.) · Last checked 2026-11-10
Ingredients it was measured on
Skin concerns studied
Other findings on the same ingredient or concern
- Skin effectThe Effectiveness and Safety of a Skin Care Product With Centella asiatica Leaf Extract, Ceramide NP, and Panthenol in Subjects With Sensitive Skin: A Prospective, Observational Study
In 88 women with sensitive skin, a face cream containing Centella asiatica leaf extract, ceramide NP and panthenol lowered the SS-10 symptom score by 66% at week 2 and 76% at week 4, with irritation, tautness, itching and redness all significantly reduced.
Human trial · 2025 · 88 people · women with sensitive skin · Chinese women with sensitive skin applying the cream to the whole face, followed up at day 2, weeks 1, 2 and 4. · Observational and self-controlled.
- Skin effectThe Ceramides Difference (CeraVe)
Ceramides, cholesterol and fatty acids are the lipids that make up the skin barrier; formulations add them to replenish it.
Brand claim · Barrier function generally; the ratio between the three lipid classes matters in the literature. · Finding · CERAMIDE NP · Ceramide AP · Ceramide EOP
- Skin effectThe 24-hr, 28-day, and 7-day post-moisturizing efficacy of ceramides 1, 3, 6-II containing moisturizing cream compared with hydrophilic cream on skin dryness and barrier disruption in senile xerosis treatment
In adults with mild-to-moderate xerosis (senile xerosis), a cream containing ceramides 1, 3, 6-II improved stratum corneum hydration, transepidermal water loss and skin pH more than a hydrophilic cream, measured at 24 hours and after 28 days of twice-daily use.
Human trial · 2019 · 24 people · adults (91.7% female, mean age ~55) with mild-to-moderate senile xerosis · Leave-on moisturizers for dry skin. The study enrolled adults with mild-to-moderate xerosis. · Small single-site study (24 participants), split-site comparison on the shins, 28 days. It shows the tested formula outperformed a basic hydrophilic cream on measured skin parameters.
- Skin effectEfficacy of ceramides and niacinamide-containing moisturizer versus hydrophilic cream in combination with topical anti-acne treatment in mild to moderate acne vulgaris: A split face, double-blinded, randomized controlled trial
In 40 people with mild-to-moderate acne all using topical benzoyl peroxide plus adapalene, a moisturiser with ceramides and niacinamide significantly improved non-inflammatory, inflammatory and total acne lesions on that side of the face versus a hydrophilic cream after 8 weeks, and decreased cutaneous irritation.
Human trial · 2024 · 40 people · patients with mild-to-moderate acne, all on topical anti-acne treatment · People on topical anti-acne medication who add a moisturiser alongside treatment, in a split-face, double-blind, randomized design for 8 weeks. · All participants used prescription/OTC anti-acne drugs (5% benzoyl peroxide + 0.1% adapalene). TEWL, hydration, sebum, pH and other biophysical measures stayed close between the two creams. This is adjunctive care.
- Skin effectNiacinamide-containing facial moisturizer improves skin barrier and benefits subjects with rosacea
A facial moisturiser containing niacinamide improved stratum corneum barrier function and skin hydration, measured instrumentally, in people with rosacea over four weeks of twice-daily use.
Human trial · 2005 · 50 people · Adults with rosacea · A leave-on facial moisturiser, applied twice daily for four weeks, in adults with rosacea. · The tested article was a finished moisturiser. Fifty participants, one centre, four weeks. The study measured barrier function and hydration.