PoreWise One finding · Human trial · 2019
Study title
The 24-hr, 28-day, and 7-day post-moisturizing efficacy of ceramides 1, 3, 6-II containing moisturizing cream compared with hydrophilic cream on skin dryness and barrier disruption in senile xerosis treatment
- Kind of evidence
- Human trial 2019 · 24 people · adults (91.7% female, mean age ~55) with mild-to-moderate senile xerosis · PMID 31585489
- Measured outcome
- Skin effect
- Year
- 2019
- Who was studied
- 24 adults (91.7% female, mean age ~55) with mild-to-moderate senile xerosis
- Sample size
- 24
- Measured outcome
- In adults with mild-to-moderate xerosis (senile xerosis), a cream containing ceramides 1, 3, 6-II improved stratum corneum hydration, transepidermal water loss and skin pH more than a hydrophilic cream, measured at 24 hours and after 28 days of twice-daily use.
- Certainty
- Moderate
- Who was measured
- Leave-on moisturizers for dry skin. The study enrolled adults with mild-to-moderate xerosis.
- Study limits
- Small single-site study (24 participants), split-site comparison on the shins, 28 days. It shows the tested formula outperformed a basic hydrophilic cream on measured skin parameters.
Where it comes from
- The 24-hr, 28-day, and 7-day post-moisturizing efficacy of ceramides 1, 3, 6-II containing moisturizing cream compared with hydrophilic cream on skin dryness and barrier disruption in senile xerosis treatment
Published by Dermatology and Therapy (Lueangarun, Tragulplaingam, Sugkraroek & Tempark) · Last checked 2026-10-26
Ingredients it was measured on
Skin concerns studied
Other findings on the same ingredient or concern
- Skin effectThe Ceramides Difference (CeraVe)
Ceramides, cholesterol and fatty acids are the lipids that make up the skin barrier; formulations add them to replenish it.
Brand claim · Barrier function generally; the ratio between the three lipid classes matters in the literature. · Finding · CERAMIDE NP · Ceramide AP · Ceramide EOP
- Skin effectThe Effectiveness and Safety of a Skin Care Product With Centella asiatica Leaf Extract, Ceramide NP, and Panthenol in Subjects With Sensitive Skin: A Prospective, Observational Study
In 88 women with sensitive skin, a face cream containing Centella asiatica leaf extract, ceramide NP and panthenol lowered the SS-10 symptom score by 66% at week 2 and 76% at week 4, with irritation, tautness, itching and redness all significantly reduced.
Human trial · 2025 · 88 people · women with sensitive skin · Chinese women with sensitive skin applying the cream to the whole face, followed up at day 2, weeks 1, 2 and 4. · Observational and self-controlled.
- Skin effectMonocentric, Vehicle-Controlled, Double-Blind Study to Assess the Short- and Long-Term Effects of a Ceramide NP C15-Containing Emollient on the Skin Microbiome and the Skin Barrier Function in Sensitive Skin
In a randomized, double-blind, vehicle-controlled split-body trial of 50 people with sensitive skin, an emollient containing Ceramide NP C15 significantly reduced transepidermal water loss in participants with an impaired skin barrier over 6 weeks.
Human trial · 2026 · 50 people · people with sensitive skin · People with sensitive skin applying the emollient in a split-body design for 6 weeks; the barrier improvement was clearest in those whose barrier was already impaired. · Exploratory; both the ceramide formulation and the vehicle improved subjective symptoms, and the significant TEWL reduction was seen specifically in the impaired-barrier subgroup.
- Skin effectEfficacy of ceramides and niacinamide-containing moisturizer versus hydrophilic cream in combination with topical anti-acne treatment in mild to moderate acne vulgaris: A split face, double-blinded, randomized controlled trial
In 40 people with mild-to-moderate acne all using topical benzoyl peroxide plus adapalene, a moisturiser with ceramides and niacinamide significantly improved non-inflammatory, inflammatory and total acne lesions on that side of the face versus a hydrophilic cream after 8 weeks, and decreased cutaneous irritation.
Human trial · 2024 · 40 people · patients with mild-to-moderate acne, all on topical anti-acne treatment · People on topical anti-acne medication who add a moisturiser alongside treatment, in a split-face, double-blind, randomized design for 8 weeks. · All participants used prescription/OTC anti-acne drugs (5% benzoyl peroxide + 0.1% adapalene). TEWL, hydration, sebum, pH and other biophysical measures stayed close between the two creams. This is adjunctive care.
- Skin effectGlycerol and the skin: holistic approach to its origin and functions
Topical glycerol improves stratum corneum hydration, barrier function and skin mechanical properties. The review also reports reduced irritation response and faster wound healing, and traces the effect to aquaporin-3 transport and to glycerol's own presence in the skin.
Review article · 2008 · Humans in the cited studies, plus animal and in-vitro work on mechanism · Leave-on products. The review discusses both healthy skin and skin with dry or barrier-impaired conditions such as atopic dermatitis. · A narrative review. It compiles mechanisms and results from other studies.