PoreWise One finding · Human trial · 2011
Study title
Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment
- Kind of evidence
- Human trial 2011 · 76 people · Women aged 30-60 with periocular wrinkles · PMID 22052267
- Measured outcome
- Skin effect
- Year
- 2011
- Who was studied
- Women aged 30-60 with periocular wrinkles
- Sample size
- 76
- Measured outcome
- Periocular wrinkle depth improved against vehicle with the 50 kDa and 130 kDa hyaluronic acid creams; after 60 days the 300, 800 and 2000 kDa creams matched vehicle on measured roughness.
- Certainty
- Moderate
- Who was measured
- Replica-based roughness measurement (mean roughness Ra, maximum roughness Rz) of periocular wrinkles, with 0.1% creams applied twice daily for 60 days.
- Study limits
- Wrinkle depth was an instrumental secondary measure on women who already had periocular lines. The trial stopped at 60 days. The five creams differed in molecular weight, shared a base formula.
Where it comes from
- Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment
Published by Journal of Drugs in Dermatology (Pavicic, Gauglitz, Lersch, Schwach-Abdellaoui, Malle, Korting & Farwick) · Last checked 2026-10-29
Ingredients it was measured on
Skin concerns studied
Other findings on the same ingredient or concern
- Skin effectEfficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment
All five 0.1% hyaluronic acid creams tested, from 50 kDa to 2000 kDa, raised skin hydration and overall elasticity above the vehicle cream applied to the other eye at 60 days.
Human trial · 2011 · 76 people · Women aged 30-60 with periocular wrinkles · 0.1% hyaluronic acid creams applied twice daily for 60 days to the eye area of women aged 30-60 with periocular wrinkles. · Sixty days, and the vehicle sat on the fellow eye. Hydration and elasticity were read by instruments. The volunteers were women aged 30-60 with eye-area wrinkles.
- How deep it getsHuman skin penetration of hyaluronic acid of different molecular weights as probed by Raman spectroscopy
Hyaluronic acid of 20-300 kDa crossed the stratum corneum in excised human skin, while hyaluronic acid of 1000-1400 kDa remained in the stratum corneum.
In vitro study · 2016 · Excised human skin sections · Excised human skin with intact stratum corneum, measured by Raman micro-imaging after topical application. · One laboratory's imaging study. Three molecular-weight grades were tested. "remains above" describes intact stratum corneum in this ex vivo setup.
- Skin effectSignificantly Enhanced Improvement in Dryness, Roughness, Fine Lines and Radiance Following Daily Use of a Novel Multi-Weight Hyaluronic Acid Plus Antioxidant Complex-Based Lotion Compared to a Single-Weight HA Plus Ceramide-Based Lotion
In a double-blind comparative study of 70 women with mild-to-moderate facial dryness, a multi-weight hyaluronic acid plus antioxidant lotion produced significantly greater improvements in clinician-graded visible dryness, roughness and fine lines over 8 weeks than a single-weight hyaluronic acid plus ceramide lotion, with improvements visible from week 2.
Human trial · 2024 · 70 people · women aged 25-65 with mild-to-moderate facial dryness and fine lines · Clinician-graded facial dryness, roughness and fine lines over 8 weeks. · Both arms used active moisturisers with SPF30; the study was funded by the product manufacturer.
- Skin effectA Randomized, Controlled Clinical Trial of a Dermocosmetic Containing Vichy Volcanic Mineralizing Water and Probiotic Fractions in Subjects with Rosacea Associated with Erythema and Sensitive Skin and Wearing Protective Masks
In a randomized split-face controlled trial in people with rosacea-associated erythema and sensitive skin, a dermocosmetic containing mineralizing water, probiotic fractions, hyaluronic acid and niacinamide significantly improved erythema at day 15 (p<0.01) and day 30 (p<0.001), with skin erythema, tightness, dryness, hydration and TEWL improving versus the untreated side (p<=0.05).
Human trial · 2023 · People with rosacea-associated erythema and sensitive skin wearing protective masks · Facial erythema, tightness, dryness, hydration and TEWL over 30 days. · The comparator is usual skin care / an untreated half-face.
- Skin effectEfficacy of a New Topical Nano-hyaluronic Acid in Humans
Eight weeks of a low-molecular-weight "nano" hyaluronic acid lotion, serum and cream reduced measured periorbital wrinkle depth by up to 40% and raised corneometer hydration by up to 96%.
Human trial · 2014 · 33 people · Women with a mean age of 45.2 years · A three-step regimen (lotion, serum, cream) built on a low-molecular-weight hyaluronic acid, used for eight weeks on women with a mean age of 45.2. · The percentages are within-group changes. 33 participants in one centre, and the material is described as "nano" hyaluronic acid.