PoreWise One finding · Human trial · 2014
Study title
Efficacy of a New Topical Nano-hyaluronic Acid in Humans
- Kind of evidence
- Human trial 2014 · 33 people · Women with a mean age of 45.2 years · PMID 24688623
- Measured outcome
- Skin effect
- Year
- 2014
- Who was studied
- Women with a mean age of 45.2 years
- Sample size
- 33
- Measured outcome
- Eight weeks of a low-molecular-weight "nano" hyaluronic acid lotion, serum and cream reduced measured periorbital wrinkle depth by up to 40% and raised corneometer hydration by up to 96%.
- Certainty
- Low
- Who was measured
- A three-step regimen (lotion, serum, cream) built on a low-molecular-weight hyaluronic acid, used for eight weeks on women with a mean age of 45.2.
- Study limits
- The percentages are within-group changes. 33 participants in one centre, and the material is described as "nano" hyaluronic acid.
Where it comes from
- Efficacy of a New Topical Nano-hyaluronic Acid in Humans
Published by Journal of Clinical and Aesthetic Dermatology (Jegasothy, Zabolotniaia & Bielfeldt) · Last checked 2026-10-29
Ingredients it was measured on
Skin concerns studied
Other findings on the same ingredient or concern
- How deep it getsFifty-kDa hyaluronic acid upregulates some epidermal genes without changing TNF-α expression in reconstituted epidermis
In reconstituted human epidermis, hyaluronic acid of about 50 kDa penetrated better than the larger grades and increased expression of genes and proteins involved in tight-junction formation and keratinocyte cohesion; its TNF-α expression stayed close from the 20 kDa grade.
In vitro study · 2011 · Reconstituted human epidermis (in vitro) · Reconstituted human epidermis incubated with hyaluronic acid of 20, 50, 130, 300, 800 and 1500 kDa. · The material tested is a defined ~50 kDa grade.
- How deep it getsHuman skin penetration of hyaluronic acid of different molecular weights as probed by Raman spectroscopy
Hyaluronic acid of 20-300 kDa crossed the stratum corneum in excised human skin, while hyaluronic acid of 1000-1400 kDa remained in the stratum corneum.
In vitro study · 2016 · Excised human skin sections · Excised human skin with intact stratum corneum, measured by Raman micro-imaging after topical application. · One laboratory's imaging study. Three molecular-weight grades were tested. "remains above" describes intact stratum corneum in this ex vivo setup.
- Skin effectHyaluronic Acid (CeraVe ingredient page)
Hyaluronic acid and its salt bind water at the skin surface, giving a plumper look immediately after application.
Brand claim · Leave-on hydrating products. · The effect is largely surface and temporary. In dry air a humectant. · Finding · Sodium hyaluronate · Hydrolyzed hyaluronic acid
- Skin effectEfficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment
Periocular wrinkle depth improved against vehicle with the 50 kDa and 130 kDa hyaluronic acid creams; after 60 days the 300, 800 and 2000 kDa creams matched vehicle on measured roughness.
Human trial · 2011 · 76 people · Women aged 30-60 with periocular wrinkles · Replica-based roughness measurement (mean roughness Ra, maximum roughness Rz) of periocular wrinkles, with 0.1% creams applied twice daily for 60 days. · Wrinkle depth was an instrumental secondary measure on women who already had periocular lines. The trial stopped at 60 days. The five creams differed in molecular weight, shared a base formula.
- Skin effectImprovement of naturally aged skin with vitamin A (retinol)
A 0.4% retinol lotion applied to the arm up to three times a week for 24 weeks reduced fine wrinkling significantly more than its vehicle in elderly subjects: score change −1.64 (95% CI −2.06 to −1.22) against −0.08 (−0.17 to 0.01) on a 0–9 severity scale.
Human trial · 2007 · 36 people · Elderly adults, mean age 87 · Elderly adults, arms. · Thirty-six participants in two senior-care facilities, average age 87, an unusual population for cosmetic use. The glycosaminoglycan and procollagen measurements that suggest a mechanism came from subgroups of six and four participants, far too small to stand on their own.