PoreWise Ingredient
Hydrolyzed hyaluronic acid
Public databaseHYDROLYZED HYALURONIC ACID
Hydrolyzed hyaluronic acid is hyaluronic acid broken into shorter chains — the INCI name for the low-molecular-weight grade. The strongest evidence comes from a 2014 human trial of 33 women with a mean age of 45.2 years: Eight weeks of a low-molecular-weight "nano" hyaluronic acid lotion, serum and cream reduced measured periorbital wrinkle depth by up to 40% and raised corneometer hydration by up to 96%. 2014 · 33 people · Women with a mean age of 45.2 years · PMID 24688623 · The percentages are within-group changes. 33 participants in one centre, and the material is described as "nano" hyaluronic acid. 13 products contain Hydrolyzed hyaluronic acid; the highest it appears is number 5 of 23.
- INCI name:
- HYDROLYZED HYALURONIC ACID
- Source:
- PubChem
Functions
Other forms of the same substance
The same substance under other INCI names, with the product count for each.
Hyaluronic acid
the acid form of the hyaluronan polymer — a chain of glucuronic acid and N-acetylglucosamine units — and, on an ingredient list, a separate INCI name from its sodium salt.
4 products
Sodium hyaluronate
the sodium salt form of hyaluronic acid — the form most often printed on an ingredient list.
34 products
Products with this ingredient
Hydrolyzed hyaluronic acid appears on 13 product ingredient lists, most often around number 18; its highest position is number 5 of 23.
| Product | Brand | Where it sits on the list |
|---|---|---|
| Hyaluronic Acid 2% + B5 | The Ordinary | 5 of 23 |
| Daily Hydrating Lotion | Cetaphil | 8 of 16 |
| Rich Hydrating Cream | Cetaphil | 11 of 33 |
| Pure Vitamin C12 Serum | La Roche-Posay | 15 of 30 |
| Deep Hydration Refreshing Eye Serum | Cetaphil | 17 of 35 |
| Hydro Boost Hydrating Gel Cleanser (Fragrance-Free) | Neutrogena | 17 of 17 |
| Niacinamide 10% + TXA 4% Serum | Anua | 18 of 51 |
| Heartleaf 77% Soothing Toner | Anua | 20 of 24 |
| Hyalu B5 Suractivated Serum | La Roche-Posay | 20 of 32 |
| Acne Control Cleanser | CeraVe | 22 of 27 |
| Foaming Facial Cleanser | CeraVe | 22 of 24 |
| SA Cream for Rough & Bumpy Skin | CeraVe | 27 of 29 |
| Skin Renewing Retinol Serum | CeraVe | 32 of 37 |
Studies and results
- 1 Skin effectEfficacy of a New Topical Nano-hyaluronic Acid in Humans
Eight weeks of a low-molecular-weight "nano" hyaluronic acid lotion, serum and cream reduced measured periorbital wrinkle depth by up to 40% and raised corneometer hydration by up to 96%.
Human trial · 2014 · 33 people · Women with a mean age of 45.2 years · A three-step regimen (lotion, serum, cream) built on a low-molecular-weight hyaluronic acid, used for eight weeks on women with a mean age of 45.2. · The percentages are within-group changes. 33 participants in one centre, and the material is described as "nano" hyaluronic acid.
- 2 How deep it getsHuman skin penetration of hyaluronic acid of different molecular weights as probed by Raman spectroscopy
Hyaluronic acid of 20-300 kDa crossed the stratum corneum in excised human skin, while hyaluronic acid of 1000-1400 kDa remained in the stratum corneum.
In vitro study · 2016 · Excised human skin sections · Excised human skin with intact stratum corneum, measured by Raman micro-imaging after topical application. · One laboratory's imaging study. Three molecular-weight grades were tested. "remains above" describes intact stratum corneum in this ex vivo setup.
- 3 How deep it getsFifty-kDa hyaluronic acid upregulates some epidermal genes without changing TNF-α expression in reconstituted epidermis
In reconstituted human epidermis, hyaluronic acid of about 50 kDa penetrated better than the larger grades and increased expression of genes and proteins involved in tight-junction formation and keratinocyte cohesion; its TNF-α expression stayed close from the 20 kDa grade.
In vitro study · 2011 · Reconstituted human epidermis (in vitro) · Reconstituted human epidermis incubated with hyaluronic acid of 20, 50, 130, 300, 800 and 1500 kDa. · The material tested is a defined ~50 kDa grade.
- 4 Skin effectHyaluronic Acid (CeraVe ingredient page)
Hyaluronic acid and its salt bind water at the skin surface, giving a plumper look immediately after application.
Brand claim · Leave-on hydrating products. · The effect is largely surface and temporary. In dry air a humectant. · Finding · Sodium hyaluronate · Hydrolyzed hyaluronic acid
Skin concerns this ingredient has been studied for
The people in each study had that concern.
Common questions
- What does Hydrolyzed hyaluronic acid do in skincare?
- Hydrolyzed hyaluronic acid is hyaluronic acid broken into shorter chains — the INCI name for the low-molecular-weight grade.
- Is Hydrolyzed hyaluronic acid the same as Hyaluronic acid and Sodium hyaluronate?
- Hyaluronic acid and Sodium hyaluronate and Hydrolyzed hyaluronic acid are the same substance under different INCI names: one polymer, differing by salt form and chain length. Ingredient lists print the name matching the material used in that formula.
- Where does Hydrolyzed hyaluronic acid sit in these formulas?
- Hydrolyzed hyaluronic acid appears in 13 products; highest on the list is number 5 of 23, in Hyaluronic Acid 2% + B5.
- Which products contain Hydrolyzed hyaluronic acid?
- Products that contain Hydrolyzed hyaluronic acid: Hyaluronic Acid 2% + B5, Daily Hydrating Lotion, Rich Hydrating Cream, Pure Vitamin C12 Serum, Deep Hydration Refreshing Eye Serum, Hydro Boost Hydrating Gel Cleanser (Fragrance-Free). Plus 7 more.
- How strong is the evidence behind Hydrolyzed hyaluronic acid?
- 4 findings on Hydrolyzed hyaluronic acid; the strongest is a 2014 human trial of 33 women with a mean age of 45.2 years.
- What did the study on Hydrolyzed hyaluronic acid measure?
- 2014 · 33 people · Women with a mean age of 45.2 years · PMID 24688623 · The percentages are within-group changes. 33 participants in one centre, and the material is described as "nano" hyaluronic acid.