PoreWise One finding · In vitro study · 2011
Study title
Fifty-kDa hyaluronic acid upregulates some epidermal genes without changing TNF-α expression in reconstituted epidermis
- Kind of evidence
- In vitro study 2011 · Reconstituted human epidermis (in vitro) · PMID 21412035
- Measured outcome
- How deep it gets
- Year
- 2011
- Who was studied
- Reconstituted human epidermis (in vitro)
- Sample size
- Measured outcome
- In reconstituted human epidermis, hyaluronic acid of about 50 kDa penetrated better than the larger grades and increased expression of genes and proteins involved in tight-junction formation and keratinocyte cohesion; its TNF-α expression stayed close from the 20 kDa grade.
- Certainty
- Low
- Who was measured
- Reconstituted human epidermis incubated with hyaluronic acid of 20, 50, 130, 300, 800 and 1500 kDa.
- Study limits
- The material tested is a defined ~50 kDa grade.
Where it comes from
- Fifty-kDa hyaluronic acid upregulates some epidermal genes without changing TNF-α expression in reconstituted epidermis
Published by Skin Pharmacology and Physiology (Farwick, Gauglitz, Pavicic, Köhler, Wegmann, Schwach-Abdellaoui, Malle, Tarabin, Schmitz & Korting) · Last checked 2026-10-29
Ingredients it was measured on
Other findings on the same ingredient or concern
- Skin effectEfficacy of a New Topical Nano-hyaluronic Acid in Humans
Eight weeks of a low-molecular-weight "nano" hyaluronic acid lotion, serum and cream reduced measured periorbital wrinkle depth by up to 40% and raised corneometer hydration by up to 96%.
Human trial · 2014 · 33 people · Women with a mean age of 45.2 years · A three-step regimen (lotion, serum, cream) built on a low-molecular-weight hyaluronic acid, used for eight weeks on women with a mean age of 45.2. · The percentages are within-group changes. 33 participants in one centre, and the material is described as "nano" hyaluronic acid.
- How deep it getsHuman skin penetration of hyaluronic acid of different molecular weights as probed by Raman spectroscopy
Hyaluronic acid of 20-300 kDa crossed the stratum corneum in excised human skin, while hyaluronic acid of 1000-1400 kDa remained in the stratum corneum.
In vitro study · 2016 · Excised human skin sections · Excised human skin with intact stratum corneum, measured by Raman micro-imaging after topical application. · One laboratory's imaging study. Three molecular-weight grades were tested. "remains above" describes intact stratum corneum in this ex vivo setup.
- Skin effectHyaluronic Acid (CeraVe ingredient page)
Hyaluronic acid and its salt bind water at the skin surface, giving a plumper look immediately after application.
Brand claim · Leave-on hydrating products. · The effect is largely surface and temporary. In dry air a humectant. · Finding · Sodium hyaluronate · Hydrolyzed hyaluronic acid