Deep Hydration Refreshing Eye Serum

Product description

An eye serum built on water, glycerin and a humectant blend (xylitylglucoside, anhydroxylitol, xylitol), with hydrolyzed hyaluronic acid and palmitoyl tripeptide-5.

Full ingredient list

Kept exactly as the source printed it, including spelling in the original.

1. 1 WATER
2. 2 DICAPRYLYL CARBONATE
3. 3 GLYCERIN
4. 4 1,2-HEXANEDIOL
5. 5 POLYGLYCERYL-6 DISTEARATE
6. 6 DISTARCH PHOSPHATE
7. 7 4-T-BUTYLCYCLOHEXANOL
8. 8 ACRYLATES/C10-30 ALKYL ACRYLATE CROSSPOLYMER
9. 9 ANHYDROXYLITOL
10. 10 BISABOLOL
11. 11 CAPRYLYL/CAPRYL GLUCOSIDE
12. 12 CETYL ALCOHOL
13. 13 CITRIC ACID
14. 14 DUNALIELLA SALINA EXTRACT
15. 15 ETHYLHEXYLGLYCERIN
16. 16 GLOBULARIA ALYPUM LEAF EXTRACT
17. 17 HYDROLYZED HYALURONIC ACID
18. 18 JOJOBA ESTERS
19. 19 PALMITOYL TRIPEPTIDE-5
20. 20 PANTHENOL
21. 21 PANTOLACTONE
22. 22 PENTYLENE GLYCOL
23. 23 PHENOXYETHANOL
24. 24 POLYGLYCERYL-3 BEESWAX
25. 25 POLYISOBUTENE
26. 26 POTASSIUM SORBATE
27. 27 SODIUM ACRYLATE/SODIUM ACRYLOYLDIMETHYL TAURATE COPOLYMER
28. 28 SODIUM BENZOATE
29. 29 SODIUM HYALURONATE
30. 30 SODIUM HYDROXIDE
31. 31 SODIUM PCA
32. 32 SORBITAN OLEATE
33. 33 TOCOPHEROL
34. 34 XYLITOL
35. 35 XYLITYLGLUCOSIDE

Water, Dicaprylyl Carbonate, Glycerin,1,2-Hexanediol, Polyglyceryl-6 Distearate, Distarch Phosphate, 4-T-Butylcyclohexanol, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Anhydroxylitol, Bisabolol, Caprylyl/Capryl Glucoside, Cetyl Alcohol, Citric Acid, Dunaliella Salina Extract (Algae), Ethylhexylglycerin, Globularia Alypum Leaf Extract(Blue Daisy), Hydrolyzed Hyaluronic Acid, Jojoba Esters, Palmitoyl Tripeptide-5, Panthenol (Vitamin B5), Pantolactone, Pentylene Glycol, Phenoxyethanol, Polyglyceryl-3 Beeswax, Polyisobutene, Potassium Sorbate, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Sodium Benzoate, Sodium Hyaluronate, Sodium Hydroxide, Sodium PCA, Sorbitan Oleate, Tocopherol (Vitamin E), Xylitol, Xylitylglucoside

Ingredient analysis

GLYCERIN · Humectants · CETYL ALCOHOL · Emollients · ETHYLHEXYLGLYCERIN · Preservatives

Evidence

• Skin effect Human trial Certainty: Moderate Primary source

  In a randomized, double-blind, four-arm crossover study of 51 healthy volunteers with dry skin, an emollient containing glycerol and petrolatum raised corneometry-measured skin moisture significantly above its vehicle (P < 0.0001) over 12 hours. The authors attributed the hydration gain to the glycerol component and the lower water loss to the petrolatum component.

  Who it applies to: Corneometry (skin moisture) and transepidermal water loss over 12 hours after one application.

  Study limits: Measured on the forearms. The significant hydration result comes from the full emollient containing both glycerol and petrolatum.

  Source:Combined effects of glycerol and petrolatum in an emollient cream: A randomized, double-blind, crossover study in healthy volunteers with dry skin
• Skin effect Review article Certainty: Moderate Primary source

  Topical glycerol improves stratum corneum hydration, barrier function and skin mechanical properties. The review also reports reduced irritation response and faster wound healing, and traces the effect to aquaporin-3 transport and to glycerol's own presence in the skin.

  Who it applies to: Leave-on products. The review discusses both healthy skin and skin with dry or barrier-impaired conditions such as atopic dermatitis.

  Study limits: A narrative review. It compiles mechanisms and results from other studies.

  Source:Glycerol and the skin: holistic approach to its origin and functions
• Skin effect Official ingredient listing Certainty: High Public database

  Glycerin is classified as a humectant in cosmetic ingredient databases: its role in a formula is to hold water.

  Who it applies to: Cosmetic formulas generally. · Ingredient database · GLYCERIN

  Study limits: Skin effect of to the stratum corneum comes from a separate review of the literature. · Ingredient database · GLYCERIN

  Source:PubChemCosIng — European Commission cosmetic ingredient database
• Skin effect Human trial Certainty: Low Primary source

  Eight weeks of a low-molecular-weight "nano" hyaluronic acid lotion, serum and cream reduced measured periorbital wrinkle depth by up to 40% and raised corneometer hydration by up to 96%.

  Who it applies to: A three-step regimen (lotion, serum, cream) built on a low-molecular-weight hyaluronic acid, used for eight weeks on women with a mean age of 45.2.

  Study limits: The percentages are within-group changes. 33 participants in one centre, and the material is described as "nano" hyaluronic acid.

  Source:Efficacy of a New Topical Nano-hyaluronic Acid in Humans
• How deep it gets In vitro study Certainty: Moderate Primary source

  Hyaluronic acid of 20-300 kDa crossed the stratum corneum in excised human skin, while hyaluronic acid of 1000-1400 kDa remained in the stratum corneum.

  Who it applies to: Excised human skin with intact stratum corneum, measured by Raman micro-imaging after topical application.

  Study limits: One laboratory's imaging study. Three molecular-weight grades were tested. "remains above" describes intact stratum corneum in this ex vivo setup.

  Source:Human skin penetration of hyaluronic acid of different molecular weights as probed by Raman spectroscopy
• How deep it gets In vitro study Certainty: Low Primary source

  In reconstituted human epidermis, hyaluronic acid of about 50 kDa penetrated better than the larger grades and increased expression of genes and proteins involved in tight-junction formation and keratinocyte cohesion; its TNF-α expression stayed close from the 20 kDa grade.

  Who it applies to: Reconstituted human epidermis incubated with hyaluronic acid of 20, 50, 130, 300, 800 and 1500 kDa.

  Study limits: The material tested is a defined ~50 kDa grade.

  Source:Fifty-kDa hyaluronic acid upregulates some epidermal genes without changing TNF-α expression in reconstituted epidermis
• Skin effect Brand claim Certainty: Moderate Public database

  Hyaluronic acid and its salt bind water at the skin surface, giving a plumper look immediately after application.

  Who it applies to: Leave-on hydrating products.

  Study limits: The effect is largely surface and temporary. In dry air a humectant. · Finding · Sodium hyaluronate · Hydrolyzed hyaluronic acid

  Source:Hyaluronic Acid (CeraVe ingredient page)PubChem
• Skin effect Human trial Certainty: Moderate Primary source

  In 88 women with sensitive skin, a face cream containing Centella asiatica leaf extract, ceramide NP and panthenol lowered the SS-10 symptom score by 66% at week 2 and 76% at week 4, with irritation, tautness, itching and redness all significantly reduced.

  Who it applies to: Chinese women with sensitive skin applying the cream to the whole face, followed up at day 2, weeks 1, 2 and 4.

  Study limits: Observational and self-controlled.

  Source:The Effectiveness and Safety of a Skin Care Product With Centella asiatica Leaf Extract, Ceramide NP, and Panthenol in Subjects With Sensitive Skin: A Prospective, Observational Study
• Skin effect Human trial Certainty: Moderate Primary source

  In 38 children with atopic dermatitis, a cream containing linoleic acid, 5% dexpanthenol and ceramide improved SCORAD significantly more than a 5% urea cream after 4 weeks (P = 0.043); both groups improved from baseline.

  Who it applies to: Children with mild-to-moderate atopic dermatitis applying the cream twice daily for 4 weeks in a randomised, double-blind, bilateral paired design.

  Study limits: Both interventions were non-prescription moisturisers: this is emollient / basic skin care. Small sample (37 completed); stratum corneum hydration and time to remission stayed close between groups.

  Source:A cream containing linoleic acid, 5% dexpanthenol and ceramide in the treatment of atopic dermatitis
• Skin effect Human trial Certainty: Moderate Primary source

  In 110 people with facial sensitive skin, a cream containing panthenol used twice daily for 28 days significantly increased stratum corneum moisture and reduced erythema index, redness (a* value) and transepidermal water loss.

  Who it applies to: People with facial sensitive skin applying the cream twice daily for 28 days.

  Study limits: Panthenol was combined with prebiotics and a probiotic lysate.

  Source:Efficacy and safety of a cream containing panthenol, prebiotics, and probiotic lysate for improving sensitive skin symptoms
• Skin effect Human trial Certainty: Low Primary source

  After facial non-ablative fractional laser treatment, a panthenol mask lowered the erythema and pigmentation indices on days 3, 7 and 14 against a saline dressing, raised stratum corneum moisture, and reduced transepidermal water loss over the same days. Sebum content was also higher in the mask group on days 7 and 14.

  Who it applies to: Skin recovering from 1550 nm and 1927 nm non-ablative fractional laser on the face. Both groups received standard post-procedure care.

  Study limits: The mask also contained madecassoside and bisabolol. It is one trial of 60 people, all recovering from the same procedure, and the published grant list includes L'Oreal Dermatological Beauty China (La Roche-Posay).

  Source:Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study
• Skin effect Human trial Certainty: Low Primary source

  In a randomized, investigator-blind, split-face trial of 40 Asian acne patients, a moisturizer containing 4-t-butylcyclohexanol, licochalcone A, ceramide and panthenol improved facial hydration more than a traditional moisturizer (p=0.001) and produced lower dryness scores (p=0.021) over 4 weeks.

  Who it applies to: Facial hydration and investigator-rated dryness over 4 weeks.

  Study limits: All participants were on prescription acne therapy (including oral isotretinoin), so the dryness is drug-induced; both sides used a moisturizer, so this is a comparison between two moisturisers; acne lesion counts decreased equally on both sides.

  Source:The efficacy of a bioactive moisturizer in mitigating side effects of acne therapies: a randomized, investigator-blind, split-face trial
• Sensitization Review article Certainty: Low Primary source

  Panthenol is treated as non-allergenic, this review argues that frequent exposure, especially on damaged skin, can produce hypersensitivity to it. The likely route is a delayed (type IV) contact reaction; immediate and mixed reactions remain possible. Proposes patch testing with the patient's own product and with panthenol 5% in petrolatum.

  Who it applies to: People who use panthenol products repeatedly, particularly those with atopic or damaged skin - the group the author says is most exposed.

  Study limits: A single-author narrative review. The mechanism it proposes is stated as likely. Read it as a reason to keep panthenol on the list of possible allergens.

  Source:Pantothenic Acid as an Unexpected Cause of Hypersensitivity to Sensitive or Atopic Skin Care Products - A Narrative Review
• Skin effect Human trial Certainty: Moderate Primary source

  All five 0.1% hyaluronic acid creams tested, from 50 kDa to 2000 kDa, raised skin hydration and overall elasticity above the vehicle cream applied to the other eye at 60 days.

  Who it applies to: 0.1% hyaluronic acid creams applied twice daily for 60 days to the eye area of women aged 30-60 with periocular wrinkles.

  Study limits: Sixty days, and the vehicle sat on the fellow eye. Hydration and elasticity were read by instruments. The volunteers were women aged 30-60 with eye-area wrinkles.

  Source:Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment
• Pore clogging Animal study Certainty: Low Primary source

  In the rabbit ear-canal assay, the nine materials graded positive were eight esters (isopropyl palmitate, isopropyl myristate, butyl stearate, isopropyl isostearate, decyl oleate, isostearyl neopentanoate, isocetyl stearate, myristyl myristate) and cocoa butter.

  Who it applies to: Materials applied to the rabbit ear canal as raw ingredients.

  Study limits: An animal assay. The rabbit ear canal reacts more readily than human skin. The abstract names the positive group.

  Source:Comedogenicity in rabbit: some cosmetic ingredients/vehicles
• Legal limits Official legal text Certainty: High Primary source

  The EU Scientific Committee on Consumer Safety concluded in 2016 that 2-phenoxyethanol is safe as a preservative at a maximum of 1.0%, which is the limit already set in Annex V/29 of the EU Cosmetics Regulation. It estimated a margin of safety of about 50 for children.

  Who it applies to: Phenoxyethanol used as a preservative in cosmetic products, at or below 1.0%.

  Study limits: The dossier behind the conclusion was submitted by Cosmetics Europe, the industry association, and the committee lowered the default toxicokinetic factor from 4.0 to 1.0 on its way to the 1.0% conclusion. The final opinion kept 1.0%.

  Source:Opinion of the Scientific Committee on Consumer Safety (SCCS) - Final version of the opinion on Phenoxyethanol in cosmetic products
• Skin effect Human trial Certainty: Moderate Primary source

  In a split-face randomized controlled trial of 50 women, a serum with 20% vitamin C, vitamin E and raspberry leaf cell culture extract significantly improved skin radiance measured by Glossymeter GL200, along with skin colour and elasticity, over 2 months.

  Who it applies to: Women aged 30-65 applying the serum to one side of the face for 2 months, with the untreated side as control.

  Study limits: Split-face with an untreated.

  Source:Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial
• Skin effect Human trial Certainty: Low Primary source

  In 31 women aged 43-65, a serum combining vitamins C and E with green tea polyphenols produced statistically significant improvements in all clinically graded parameters over 12 weeks, including enhanced skin smoothness and radiance, plus an ultrasound-measured increase in skin density.

  Who it applies to: Women aged 43-65 with photoaged facial skin, applying the serum twice daily for 12 weeks.

  Study limits: Radiance was a clinical grading parameter.

  Source:Novel Vitamin C and E and Green Tea Polyphenols Combination Serum Improves Photoaged Facial Skin
• Skin effect Human trial Certainty: Low Primary source

  In a double-blind trial that split each scar into two halves. Or made worse, the cosmetic appearance.

  Who it applies to: Scars after surgical removal of skin cancer, treated twice daily for four weeks with a petrolatum-based ointment.

  Study limits: Fifteen people, one centre, published in 1999. Pigmentation, or the job vitamin E does inside a formula, where it slows oxidation of the oils.

  Source:The effects of topical vitamin E on the cosmetic appearance of scars
• Sensitization Human trial Certainty: Low Primary source

  In the same split-scar trial, 33% of the participants developed contact dermatitis to the vitamin E ointment.

  Who it applies to: Vitamin E in a petrolatum-based ointment applied to healing surgical wounds, twice daily for four weeks.

  Study limits: Small trial (15 people) with a single product.

  Source:The effects of topical vitamin E on the cosmetic appearance of scars

Related skin concerns

Skin concerns with evidence for ingredients on this list.

Formula history

1 version of this formula on record.

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