PoreWise
中文

Skin concern

Eczema and atopic dermatitis

Primary source

Eczema and atopic dermatitis: a chronic, relapsing, intensely itchy inflammatory skin condition rooted in barrier dysfunction and a type-2 immune response. The strongest evidence comes from a 2024 human trial: In 38 children with atopic dermatitis, a cream containing linoleic acid, 5% dexpanthenol and ceramide improved SCORAD significantly more than a 5% urea cream after 4 weeks (P = 0.043); both groups improved from baseline. 1 ingredient has evidence for Eczema and atopic dermatitis: Panthenol.

The two studies tested emollient or moisturizer care in diagnosed patients as supportive therapy. This is adjunct care alongside a clinician's plan. Diagnosis and prescription treatment stay with a clinician.

Where the definition comes from

Source wording

“Atopic dermatitis is a chronic, relapsing, inflammatory skin disease characterized by a defective skin barrier and type-2 immune dysregulation.” — Ständer, N Engl J Med 2021 (PMID 33761208).

Atopic Dermatitis. New England Journal of Medicine (Ständer S)

Ingredients at a glance

2024 · 38 people · children with atopic dermatitis (37 completed) · PMID 33865303

Ingredient Measured outcome Based on Certainty Year
Panthenol Skin effect Human trial Moderate 2024
— Skin effect Human trial Low 2019

Studies and results

  1. 1 Panthenol Skin effect
    A cream containing linoleic acid, 5% dexpanthenol and ceramide in the treatment of atopic dermatitis

    In 38 children with atopic dermatitis, a cream containing linoleic acid, 5% dexpanthenol and ceramide improved SCORAD significantly more than a 5% urea cream after 4 weeks (P = 0.043); both groups improved from baseline.

    Human trial · 2024 · 38 people · children with atopic dermatitis (37 completed) · Children with mild-to-moderate atopic dermatitis applying the cream twice daily for 4 weeks in a randomised, double-blind, bilateral paired design. · Both interventions were non-prescription moisturisers: this is emollient / basic skin care. Small sample (37 completed); stratum corneum hydration and time to remission stayed close between groups.

    PMID 33865303

    Read the full finding →
    Source:A cream containing linoleic acid, 5% dexpanthenol and ceramide in the treatment of atopic dermatitis

Study limits

Study conditions and measured outcomes.

  • Panthenol Human trial · 2024

    Both interventions were non-prescription moisturisers: this is emollient / basic skin care. Small sample (37 completed); stratum corneum hydration and time to remission stayed close between groups.

  • ev-eczema-pseudoceramide-moisturizer Human trial · 2019

    2019 · 44 people · 44 Japanese subjects with mild atopic dermatitis (27 treated, 17 untreated). · PMID 30084152

Products with a basis for this

24 products · 10% Niacinamide Booster · 3-Ceramide + Panthenol Moisture Barrier Cream · 2024 · 38 people · children with atopic dermatitis (37 completed) · PMID 33865303

Research-backed approaches

These studies measured finished products and whole routines.

  1. 1 Skin effect
    Efficacy of a moisturizer containing a pseudo-ceramide and a eucalyptus extract for Japanese patients with mild atopic dermatitis in the summer

    In 44 Japanese people with mild atopic dermatitis, a moisturising gel containing a pseudo-ceramide and eucalyptus extract improved dryness significantly more than the untreated side over 4 weeks, and erythema, itchiness, skin hydration and quality of life improved in the treated group.

    Human trial · 2019 · 44 people · Japanese subjects with mild atopic dermatitis (27 treated, 17 untreated) · People with mild atopic dermatitis applying the moisturising gel twice daily for 4 weeks, including in summer. · 2019 · 44 people · 44 Japanese subjects with mild atopic dermatitis (27 treated, 17 untreated). · PMID 30084152

    PMID 30084152

    Read the full finding →
    Source:Efficacy of a moisturizer containing a pseudo-ceramide and a eucalyptus extract for Japanese patients with mild atopic dermatitis in the summer

Common questions

Which ingredients have been studied for Eczema and atopic dermatitis?
Ingredients with evidence for Eczema and atopic dermatitis: Panthenol.
How many people were studied?
2 findings · 2024 · 38 people · children with atopic dermatitis (37 completed) · PMID 33865303
What can I use for Eczema and atopic dermatitis?
Panthenol · 2024 · 38 people · children with atopic dermatitis (37 completed) · PMID 33865303
Can I use these every day for Eczema and atopic dermatitis?
Children with mild-to-moderate atopic dermatitis applying the cream twice daily for 4 weeks in a randomised, double-blind, bilateral paired design（2024 · 38 participants · 38 children with atopic dermatitis (37 completed) · PMID 33865303） People with mild atopic dermatitis applying the moisturising gel twice daily for 4 weeks, including in summer（2019 · 44 participants · 44 Japanese subjects with mild atopic dermatitis (27 treated, 17 untreated) · PMID 30084152）

Other concerns

Acne marks and scars Acne and breakouts Barrier damage Blackheads Bumps and rough texture Closed comedones Combination skin Dark circles Dark spots Skincare for deeper skin tones Dehydrated skin Dryness Dull skin Hyperpigmentation Large pores Loss of firmness Melasma Skincare for men Oily skin Skincare while on acne medication Peeling and flaking Perioral dermatitis Skincare during pregnancy Psoriasis Facial redness Rosacea Sebaceous filaments Sensitive skin Sun damage Sun protection Teenage skin Uneven skin tone Wrinkles and fine lines