3-Ceramide + Panthenol Moisture Barrier Cream

Product description

A cream with three ceramides and panthenol for the moisture barrier.

Full ingredient list

Kept exactly as the source printed it, including spelling in the original.

1. 1 WATER
2. 2 PANTHENOL
3. 3 BUTYLENE GLYCOL
4. 4 PROPANEDIOL
5. 5 CAPRYLIC/CAPRIC TRIGLYCERIDE
6. 6 GLYCERIN
7. 7 CETYL ETHYLHEXANOATE
8. 8 BEHENYL ALCOHOL
9. 9 OCTYLDODECANOL
10. 10 PHENYL TRIMETHICONE
11. 11 VINYL DIMETHICONE
12. 12 1,2-HEXANEDIOL
13. 13 BIS-DIGLYCERYL POLYACYLADIPATE-2
14. 14 PENTYLENE GLYCOL
15. 15 CAPRYLYL METHICONE
16. 16 CENTELLA ASIATICA EXTRACT
17. 17 POLYGLYCERYL-3 METHYLGLUCOSE DISTEARATE
18. 18 BETAINE
19. 19 C14-22 ALCOHOLS
20. 20 CERAMIDE NP
21. 21 PHYTOSTEROLS
22. 22 HYDROXYETHYL ACRYLATE/SODIUM ACRYLOYLDIMETHYL TAURATE COPOLYMER
23. 23 HYDROGENATED RICE BRAN OIL
24. 24 C12-20 ALKYL GLUCOSIDE
25. 25 AMMONIUM ACRYLOYLDIMETHYLTAURATE/VP COPOLYMER
26. 26 GLYCERYL STEARATE
27. 27 DIMETHICONOL
28. 28 GLYCERYL CAPRYLATE
29. 29 SODIUM STEAROYL GLUTAMATE
30. 30 HYDROGENATED LECITHIN
31. 31 GLYCERYL GLUCOSIDE
32. 32 ACRYLATES/C10-30 ALKYL ACRYLATE CROSSPOLYMER
33. 33 TROMETHAMINE
34. 34 SODIUM PHYTATE
35. 35 POLYGLYCERYL-10 STEARATE
36. 36 ETHYLHEXYLGLYCERIN
37. 37 SODIUM HYALURONATE
38. 38 ETHYLHEXYL OLIVATE
39. 39 DIPROPYLENE GLYCOL
40. 40 SODIUM ACRYLATES COPOLYMER
41. 41 POLYGLYCERYL-4 OLEATE
42. 42 LINOLENIC ACID
43. 43 POLYGLYCERYL-10 LAURATE
44. 44 SPHINGOLIPIDS
45. 45 PHOSPHATIDYLCHOLINE
46. 46 4-TERPINEOL
47. 47 ALLANTOIN
48. 48 ECTOIN
49. 49 HYALURONIC ACID
50. 50 SQUALANE
51. 51 LECITHIN
52. 52 ASIATICOSIDE
53. 53 ESCIN
54. 54 MADECASSIC ACID
55. 55 ASIATIC ACID
56. 56 BETA-SITOSTEROL
57. 57 TREMELLA FUCIFORMIS (MUSHROOM) SPOROCARP EXTRACT
58. 58 CERAMIDE AP
59. 59 CERAMIDE EOP
60. 60 GLYCINE
61. 61 GLUTAMIC ACID
62. 62 SERINE
63. 63 ALANINE
64. 64 LYSINE
65. 65 ARGININE
66. 66 PROLINE
67. 67 THREONINE

Water, Panthenol, Butylene Glycol, Propanediol, Caprylic/Capric Triglyceride, Glycerin, Cetyl Ethylhexanoate, Behenyl Alcohol, Octyldodecanol, Phenyl Trimethicone, Vinyl Dimethicone, 1,2-Hexanediol, Bis-Diglyceryl Polyacyladipate-2, Pentylene Glycol, Caprylyl Methicone, Centella Asiatica Extract, Polyglyceryl-3 Methylglucose Distearate, Betaine, C14-22 Alcohols, Ceramide NP, Phytosterols, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Hydrogenated Rice Bran Oil, C12-20 Alkyl Glucoside, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Glyceryl Stearate, Dimethiconol, Glyceryl Caprylate, Sodium Stearoyl Glutamate, Hydrogenated Lecithin, Glyceryl Glucoside, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Tromethamine, Sodium Phytate, Polyglyceryl-10 Stearate, Ethylhexylglycerin, Sodium Hyaluronate, Ethylhexyl Olivate, Dipropylene Glycol, Sodium Acrylates Copolymer, Polyglyceryl-4 Oleate, Linolenic Acid, Polyglyceryl-10 Laurate, Sphingolipids, Phosphatidylcholine, 4-Terpineol, Allantoin, Ectoin, Hyaluronic Acid, Squalane, Lecithin, Asiaticoside, Escin, Madecassic Acid, Asiatic Acid, Beta-Sitosterol, Tremella Fuciformis (Mushroom) Extract, Ceramide AP, Ceramide Eop, Glycine, Glutamic Acid, Serine, Alanine, Lysine, Arginine, Proline, Threonine

Ingredient analysis

CERAMIDE NP · Barrier lipids · PANTHENOL · Humectants · CAPRYLIC/CAPRIC TRIGLYCERIDE · Emollients

Evidence

• Skin effect Human trial Certainty: Moderate Primary source

  In 88 women with sensitive skin, a face cream containing Centella asiatica leaf extract, ceramide NP and panthenol lowered the SS-10 symptom score by 66% at week 2 and 76% at week 4, with irritation, tautness, itching and redness all significantly reduced.

  Who it applies to: Chinese women with sensitive skin applying the cream to the whole face, followed up at day 2, weeks 1, 2 and 4.

  Study limits: Observational and self-controlled.

  Source:The Effectiveness and Safety of a Skin Care Product With Centella asiatica Leaf Extract, Ceramide NP, and Panthenol in Subjects With Sensitive Skin: A Prospective, Observational Study
• Skin effect Human trial Certainty: Moderate Primary source

  In a randomized, double-blind, vehicle-controlled split-body trial of 50 people with sensitive skin, an emollient containing Ceramide NP C15 significantly reduced transepidermal water loss in participants with an impaired skin barrier over 6 weeks.

  Who it applies to: People with sensitive skin applying the emollient in a split-body design for 6 weeks; the barrier improvement was clearest in those whose barrier was already impaired.

  Study limits: Exploratory; both the ceramide formulation and the vehicle improved subjective symptoms, and the significant TEWL reduction was seen specifically in the impaired-barrier subgroup.

  Source:Monocentric, Vehicle-Controlled, Double-Blind Study to Assess the Short- and Long-Term Effects of a Ceramide NP C15-Containing Emollient on the Skin Microbiome and the Skin Barrier Function in Sensitive Skin
• Skin effect Human trial Certainty: Moderate Primary source

  In adults with mild-to-moderate xerosis (senile xerosis), a cream containing ceramides 1, 3, 6-II improved stratum corneum hydration, transepidermal water loss and skin pH more than a hydrophilic cream, measured at 24 hours and after 28 days of twice-daily use.

  Who it applies to: Leave-on moisturizers for dry skin. The study enrolled adults with mild-to-moderate xerosis.

  Study limits: Small single-site study (24 participants), split-site comparison on the shins, 28 days. It shows the tested formula outperformed a basic hydrophilic cream on measured skin parameters.

  Source:The 24-hr, 28-day, and 7-day post-moisturizing efficacy of ceramides 1, 3, 6-II containing moisturizing cream compared with hydrophilic cream on skin dryness and barrier disruption in senile xerosis treatment
• Skin effect Human trial Certainty: Moderate Primary source

  In 40 people with mild-to-moderate acne all using topical benzoyl peroxide plus adapalene, a moisturiser with ceramides and niacinamide significantly improved non-inflammatory, inflammatory and total acne lesions on that side of the face versus a hydrophilic cream after 8 weeks, and decreased cutaneous irritation.

  Who it applies to: People on topical anti-acne medication who add a moisturiser alongside treatment, in a split-face, double-blind, randomized design for 8 weeks.

  Study limits: All participants used prescription/OTC anti-acne drugs (5% benzoyl peroxide + 0.1% adapalene). TEWL, hydration, sebum, pH and other biophysical measures stayed close between the two creams. This is adjunctive care.

  Source:Efficacy of ceramides and niacinamide-containing moisturizer versus hydrophilic cream in combination with topical anti-acne treatment in mild to moderate acne vulgaris: A split face, double-blinded, randomized controlled trial
• Skin effect Brand claim Certainty: High Public database

  Ceramides, cholesterol and fatty acids are the lipids that make up the skin barrier; formulations add them to replenish it.

  Who it applies to: Barrier function generally; the ratio between the three lipid classes matters in the literature.

  Study limits: Finding · CERAMIDE NP · Ceramide AP · Ceramide EOP

  Source:The Ceramides Difference (CeraVe)CosIng — European Commission cosmetic ingredient database
• Skin effect Human trial Certainty: Moderate Primary source

  In 38 children with atopic dermatitis, a cream containing linoleic acid, 5% dexpanthenol and ceramide improved SCORAD significantly more than a 5% urea cream after 4 weeks (P = 0.043); both groups improved from baseline.

  Who it applies to: Children with mild-to-moderate atopic dermatitis applying the cream twice daily for 4 weeks in a randomised, double-blind, bilateral paired design.

  Study limits: Both interventions were non-prescription moisturisers: this is emollient / basic skin care. Small sample (37 completed); stratum corneum hydration and time to remission stayed close between groups.

  Source:A cream containing linoleic acid, 5% dexpanthenol and ceramide in the treatment of atopic dermatitis
• Skin effect Human trial Certainty: Moderate Primary source

  In 110 people with facial sensitive skin, a cream containing panthenol used twice daily for 28 days significantly increased stratum corneum moisture and reduced erythema index, redness (a* value) and transepidermal water loss.

  Who it applies to: People with facial sensitive skin applying the cream twice daily for 28 days.

  Study limits: Panthenol was combined with prebiotics and a probiotic lysate.

  Source:Efficacy and safety of a cream containing panthenol, prebiotics, and probiotic lysate for improving sensitive skin symptoms
• Skin effect Human trial Certainty: Low Primary source

  After facial non-ablative fractional laser treatment, a panthenol mask lowered the erythema and pigmentation indices on days 3, 7 and 14 against a saline dressing, raised stratum corneum moisture, and reduced transepidermal water loss over the same days. Sebum content was also higher in the mask group on days 7 and 14.

  Who it applies to: Skin recovering from 1550 nm and 1927 nm non-ablative fractional laser on the face. Both groups received standard post-procedure care.

  Study limits: The mask also contained madecassoside and bisabolol. It is one trial of 60 people, all recovering from the same procedure, and the published grant list includes L'Oreal Dermatological Beauty China (La Roche-Posay).

  Source:Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study
• Skin effect Human trial Certainty: Low Primary source

  In a randomized, investigator-blind, split-face trial of 40 Asian acne patients, a moisturizer containing 4-t-butylcyclohexanol, licochalcone A, ceramide and panthenol improved facial hydration more than a traditional moisturizer (p=0.001) and produced lower dryness scores (p=0.021) over 4 weeks.

  Who it applies to: Facial hydration and investigator-rated dryness over 4 weeks.

  Study limits: All participants were on prescription acne therapy (including oral isotretinoin), so the dryness is drug-induced; both sides used a moisturizer, so this is a comparison between two moisturisers; acne lesion counts decreased equally on both sides.

  Source:The efficacy of a bioactive moisturizer in mitigating side effects of acne therapies: a randomized, investigator-blind, split-face trial
• Sensitization Review article Certainty: Low Primary source

  Panthenol is treated as non-allergenic, this review argues that frequent exposure, especially on damaged skin, can produce hypersensitivity to it. The likely route is a delayed (type IV) contact reaction; immediate and mixed reactions remain possible. Proposes patch testing with the patient's own product and with panthenol 5% in petrolatum.

  Who it applies to: People who use panthenol products repeatedly, particularly those with atopic or damaged skin - the group the author says is most exposed.

  Study limits: A single-author narrative review. The mechanism it proposes is stated as likely. Read it as a reason to keep panthenol on the list of possible allergens.

  Source:Pantothenic Acid as an Unexpected Cause of Hypersensitivity to Sensitive or Atopic Skin Care Products - A Narrative Review
• Skin effect Human trial Certainty: Moderate Primary source

  In a randomized, double-blind, four-arm crossover study of 51 healthy volunteers with dry skin, an emollient containing glycerol and petrolatum raised corneometry-measured skin moisture significantly above its vehicle (P < 0.0001) over 12 hours. The authors attributed the hydration gain to the glycerol component and the lower water loss to the petrolatum component.

  Who it applies to: Corneometry (skin moisture) and transepidermal water loss over 12 hours after one application.

  Study limits: Measured on the forearms. The significant hydration result comes from the full emollient containing both glycerol and petrolatum.

  Source:Combined effects of glycerol and petrolatum in an emollient cream: A randomized, double-blind, crossover study in healthy volunteers with dry skin
• Skin effect Review article Certainty: Moderate Primary source

  Topical glycerol improves stratum corneum hydration, barrier function and skin mechanical properties. The review also reports reduced irritation response and faster wound healing, and traces the effect to aquaporin-3 transport and to glycerol's own presence in the skin.

  Who it applies to: Leave-on products. The review discusses both healthy skin and skin with dry or barrier-impaired conditions such as atopic dermatitis.

  Study limits: A narrative review. It compiles mechanisms and results from other studies.

  Source:Glycerol and the skin: holistic approach to its origin and functions
• Skin effect Official ingredient listing Certainty: High Public database

  Glycerin is classified as a humectant in cosmetic ingredient databases: its role in a formula is to hold water.

  Who it applies to: Cosmetic formulas generally. · Ingredient database · GLYCERIN

  Study limits: Skin effect of to the stratum corneum comes from a separate review of the literature. · Ingredient database · GLYCERIN

  Source:PubChemCosIng — European Commission cosmetic ingredient database
• Skin effect Human trial Certainty: Moderate Primary source

  All five 0.1% hyaluronic acid creams tested, from 50 kDa to 2000 kDa, raised skin hydration and overall elasticity above the vehicle cream applied to the other eye at 60 days.

  Who it applies to: 0.1% hyaluronic acid creams applied twice daily for 60 days to the eye area of women aged 30-60 with periocular wrinkles.

  Study limits: Sixty days, and the vehicle sat on the fellow eye. Hydration and elasticity were read by instruments. The volunteers were women aged 30-60 with eye-area wrinkles.

  Source:Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment
• How deep it gets In vitro study Certainty: Moderate Primary source

  Hyaluronic acid of 20-300 kDa crossed the stratum corneum in excised human skin, while hyaluronic acid of 1000-1400 kDa remained in the stratum corneum.

  Who it applies to: Excised human skin with intact stratum corneum, measured by Raman micro-imaging after topical application.

  Study limits: One laboratory's imaging study. Three molecular-weight grades were tested. "remains above" describes intact stratum corneum in this ex vivo setup.

  Source:Human skin penetration of hyaluronic acid of different molecular weights as probed by Raman spectroscopy
• Skin effect Brand claim Certainty: Moderate Public database

  Hyaluronic acid and its salt bind water at the skin surface, giving a plumper look immediately after application.

  Who it applies to: Leave-on hydrating products.

  Study limits: The effect is largely surface and temporary. In dry air a humectant. · Finding · Sodium hyaluronate · Hydrolyzed hyaluronic acid

  Source:Hyaluronic Acid (CeraVe ingredient page)PubChem
• Skin effect Human trial Certainty: Moderate Primary source

  Periocular wrinkle depth improved against vehicle with the 50 kDa and 130 kDa hyaluronic acid creams; after 60 days the 300, 800 and 2000 kDa creams matched vehicle on measured roughness.

  Who it applies to: Replica-based roughness measurement (mean roughness Ra, maximum roughness Rz) of periocular wrinkles, with 0.1% creams applied twice daily for 60 days.

  Study limits: Wrinkle depth was an instrumental secondary measure on women who already had periocular lines. The trial stopped at 60 days. The five creams differed in molecular weight, shared a base formula.

  Source:Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment
• Skin effect Human trial Certainty: Moderate Primary source

  In a double-blind comparative study of 70 women with mild-to-moderate facial dryness, a multi-weight hyaluronic acid plus antioxidant lotion produced significantly greater improvements in clinician-graded visible dryness, roughness and fine lines over 8 weeks than a single-weight hyaluronic acid plus ceramide lotion, with improvements visible from week 2.

  Who it applies to: Clinician-graded facial dryness, roughness and fine lines over 8 weeks.

  Study limits: Both arms used active moisturisers with SPF30; the study was funded by the product manufacturer.

  Source:Significantly Enhanced Improvement in Dryness, Roughness, Fine Lines and Radiance Following Daily Use of a Novel Multi-Weight Hyaluronic Acid Plus Antioxidant Complex-Based Lotion Compared to a Single-Weight HA Plus Ceramide-Based Lotion
• Skin effect Human trial Certainty: Low Primary source

  In a randomized split-face controlled trial in people with rosacea-associated erythema and sensitive skin, a dermocosmetic containing mineralizing water, probiotic fractions, hyaluronic acid and niacinamide significantly improved erythema at day 15 (p<0.01) and day 30 (p<0.001), with skin erythema, tightness, dryness, hydration and TEWL improving versus the untreated side (p<=0.05).

  Who it applies to: Facial erythema, tightness, dryness, hydration and TEWL over 30 days.

  Study limits: The comparator is usual skin care / an untreated half-face.

  Source:A Randomized, Controlled Clinical Trial of a Dermocosmetic Containing Vichy Volcanic Mineralizing Water and Probiotic Fractions in Subjects with Rosacea Associated with Erythema and Sensitive Skin and Wearing Protective Masks

Related skin concerns

Skin concerns with evidence for ingredients on this list.

Formula history

1 version of this formula on record.

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