PoreWise Skin concern
Perioral dermatitis
Primary sourcePerioral dermatitis: a common facial condition with acne-like, often eczema-like eruptions around the mouth, nose or eyes. Mainstream care is “zero therapy” (stopping triggers) plus a clinician's plan; gentle, non-medicated skincare can be a low-risk adjunct. The strongest evidence comes from a 2014 human trial: In an 8-week open study of 51 people with perioral dermatitis, twice-daily use of a drug-free soothing cosmetic fluid was associated with significant within-group improvement in perioral dermatitis severity (PODSI) and in itching, skin tightness and appearance over time; the improvement was better.
2014 · 51 people · PMID 25143674; 2020 · 48 people · PMID 31660683. See a clinician first; gentle skincare can be a low-risk adjunct. Diagnosis and prescription treatment stay with a clinician.
Where the definition comes from
Source wording
“Perioral dermatitis is a common cutaneous condition characterized by acneiform facial eruptions often with an eczematous appearance.” — Searle et al., J Cosmet Dermatol 2021 (PMID 33751778).
Perioral dermatitis: Diagnosis, proposed etiologies, and management. Journal of Cosmetic Dermatology (Searle T)
Ingredients at a glance
2014 · 51 people · patients with clinically diagnosed perioral dermatitis treated for 8 weeks at two German university dermatology departments, sex or subtype breakdown · PMID 25143674
| Ingredient | Measured outcome | Based on | Certainty | Year |
|---|---|---|---|---|
| — | Skin effect | Human trial | Very low | 2014 |
| — | Skin effect | Human trial | Very low | 2020 |
Study limits
Study conditions and measured outcomes.
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ev-perioral-dermatitis-tolpod-fluid Human trial · 2014
Open-label, non-randomized, non-blinded single-arm study compared with a non-concurrent historical vehicle group, stopping the triggering product, or natural resolution. A 2022 systematic review of perioral dermatitis found low to very low certainty evidence, all for drug interventions.
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ev-perioral-dermatitis-trpv1-cream Human trial · 2020
Open-label, non-blinded and uncontrolled. A systematic review of perioral dermatitis reports low to very low certainty evidence, with drug interventions and trigger avoidance as the mainstay; a skin care cream is management.
Research-backed approaches
These studies measured finished products and whole routines.
- 1 Skin effectEfficacy and Safety Results of a Drug-Free Cosmetic Fluid for Perioral Dermatitis: The Toleriane Fluide Efficacy in Perioral Dermatitis (TOLPOD) Study
In an 8-week open study of 51 people with perioral dermatitis, twice-daily use of a drug-free soothing cosmetic fluid was associated with significant within-group improvement in perioral dermatitis severity (PODSI) and in itching, skin tightness and appearance over time; the improvement was better.
Human trial · 2014 · 51 people · patients with clinically diagnosed perioral dermatitis treated for 8 weeks at two German university dermatology departments, sex or subtype breakdown · Gentle, drug-free cosmetic or emollient-type skincare as low-risk supportive care for perioral dermatitis, the efficacy of any specific skincare active, or a substitute for medical treatment. · Open-label, non-randomized, non-blinded single-arm study compared with a non-concurrent historical vehicle group, stopping the triggering product, or natural resolution. A 2022 systematic review of perioral dermatitis found low to very low certainty evidence, all for drug interventions.
- 2 Skin effectEfficacy of a skin care cream with TRPV1 inhibitor 4-t-butylcyclohexanol in the topical therapy of perioral dermatitis
In 48 people with perioral dermatitis, a skin care cream containing the TRPV1 inhibitor 4-t-butylcyclohexanol significantly reduced perioral dermatitis severity scores, subjective numerical ratings, transepidermal water loss, erythema and improved quality of life over 8 weeks.
Human trial · 2020 · 48 people · patients with perioral dermatitis · People with perioral dermatitis using the skin care cream for 8 weeks. · Open-label, non-blinded and uncontrolled. A systematic review of perioral dermatitis reports low to very low certainty evidence, with drug interventions and trigger avoidance as the mainstay; a skin care cream is management.
Common questions
- How many people were studied?
- 2 findings · 2014 · 51 people · patients with clinically diagnosed perioral dermatitis treated for 8 weeks at two German university dermatology departments, sex or subtype breakdown · PMID 25143674
- What can I use for Perioral dermatitis?
- 2014 · 51 people · patients with clinically diagnosed perioral dermatitis treated for 8 weeks at two German university dermatology departments, sex or subtype breakdown · PMID 25143674