PoreWise One finding · Human trial · 2026
Study title
A Randomized Controlled Trial of the Genistein Plus Bakuchiol and Vitamins (GEN(+)) Product for Male Facial Skin: Effects on Skin Appearance and Properties
- Kind of evidence
- Human trial 2026 · 80 people · men aged 45-65 (40/40) · PMID 41562471
- Measured outcome
- Skin effect
- Year
- 2026
- Who was studied
- 80 men aged 45-65 (40/40)
- Sample size
- 80
- Measured outcome
- In a 12-week randomized, double-blind, placebo-controlled trial of 80 men aged 45-65, a product combining genistein, bakuchiol and vitamins significantly improved cheek skin lightening, colour consistency, forehead spots and skin roughness versus placebo; most other measured parameters showed similar between-group difference.
- Certainty
- Low
- Who was measured
- Men aged 45-65 applying the product twice daily for 12 weeks.
- Study limits
- Melanin, erythema, acne, elasticity, hydration, barrier and wrinkle parameters showed similar between-group differences; the authors describe the result as promising. Male-specific skincare trials are rare, and "for men" is largely a marketing label.
Where it comes from
- A Randomized Controlled Trial of the Genistein Plus Bakuchiol and Vitamins (GEN(+)) Product for Male Facial Skin: Effects on Skin Appearance and Properties
Published by Skin Research and Technology (Na Takuathung M, et al.) · Last checked 2026-11-10
Ingredients it was measured on
Skin concerns studied
Other findings on the same ingredient or concern
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Human trial · 2013 · 33 people · healthy Asian men · Facial skin surface parameters (SELS) measured by Visioscan over 60 days. · Reported as a placebo-controlled comparative study; the formulation is a plant-extract combination.
- Skin effectThe safety and efficacy of 3% Cannabis seeds extract cream for reduction of human cheek skin sebum and erythema content
In a 12-week single-blind, base-controlled study in healthy men, a cream containing 3% Cannabis seed extract significantly reduced cheek sebum and erythema compared with the extract-free base (p<0.05).
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- Skin effectFabrication of Tamarindus indica seeds extract loaded-cream for photo-aged skin: Visioscan studies
In a 12-week base-controlled study of 11 healthy men, a cream containing 4% Tamarindus indica seed extract significantly improved skin elasticity, moisture and Visioscan scaliness, wrinkle, smoothness and roughness parameters (p<=0.05), while the same emulsion the base emulsion showed similar change (p>0.05).
Human trial · 2017 · 11 people · healthy male volunteers · Cheek skin elasticity, moisture and surface parameters over 12 weeks. · Very small sample (11 men); single-centre regional journal.