PoreWise One finding · Human trial · 2023
Study title
Ceramide-Containing Adjunctive Skin Care for Skin Barrier Restoration During Acne Vulgaris Treatment
- Kind of evidence
- Human trial 2023 · Acne patients using adapalene/benzoyl peroxide gel · PMID 37276158
- Measured outcome
- Skin effect
- Year
- 2023
- Who was studied
- Acne patients using adapalene/benzoyl peroxide gel.
- Sample size
- Measured outcome
- In a double-blind randomized controlled trial of acne patients all using adapalene 0.3%/benzoyl peroxide 2.5% gel, adding a ceramide-containing cleanser and facial lotion for 12 weeks yielded significantly lower inflammatory lesion counts than a basic face-wash control, with significantly better TEWL and lower investigator scores for dryness, erythema and scaling.
- Certainty
- Moderate
- Who was measured
- Inflammatory lesion counts, TEWL, dryness, erythema and scaling during 12 weeks of acne treatment.
- Study limits
- Lesion-count numbers or ceramide concentration; the intervention is a cleanser-plus-lotion combination; the background acne drug was used by both groups.
Where it comes from
- Ceramide-Containing Adjunctive Skin Care for Skin Barrier Restoration During Acne Vulgaris Treatment
Published by Journal of Drugs in Dermatology (Draelos ZD, 2023) · Last checked 2026-11-10
Skin concerns studied
Other findings on the same ingredient or concern
- Skin effectEfficacy of ceramides and niacinamide-containing moisturizer versus hydrophilic cream in combination with topical anti-acne treatment in mild to moderate acne vulgaris: A split face, double-blinded, randomized controlled trial
In 40 people with mild-to-moderate acne all using topical benzoyl peroxide plus adapalene, a moisturiser with ceramides and niacinamide significantly improved non-inflammatory, inflammatory and total acne lesions on that side of the face versus a hydrophilic cream after 8 weeks, and decreased cutaneous irritation.
Human trial · 2024 · 40 people · patients with mild-to-moderate acne, all on topical anti-acne treatment · People on topical anti-acne medication who add a moisturiser alongside treatment, in a split-face, double-blind, randomized design for 8 weeks. · All participants used prescription/OTC anti-acne drugs (5% benzoyl peroxide + 0.1% adapalene). TEWL, hydration, sebum, pH and other biophysical measures stayed close between the two creams. This is adjunctive care.
- Skin effectThe efficacy of a bioactive moisturizer in mitigating side effects of acne therapies: a randomized, investigator-blind, split-face trial
In a randomized, investigator-blind, split-face trial of 40 Asian acne patients, a moisturizer containing 4-t-butylcyclohexanol, licochalcone A, ceramide and panthenol improved facial hydration more than a traditional moisturizer (p=0.001) and produced lower dryness scores (p=0.021) over 4 weeks.
Human trial · 2026 · 40 people · Asian acne patients using adapalene/benzoyl peroxide gel or oral isotretinoin · Facial hydration and investigator-rated dryness over 4 weeks. · All participants were on prescription acne therapy (including oral isotretinoin), so the dryness is drug-induced; both sides used a moisturizer, so this is a comparison between two moisturisers; acne lesion counts decreased equally on both sides.
- Skin effectEnhanced efficacy of a facial hydrating serum in subjects with normal or self-perceived dry skin
In a randomized, evaluator-blinded study of 32 women, adding a facial hydrating serum to a moisturizer for 2 weeks produced statistically significant improvements in investigator-graded facial dryness and skin softness compared with using the moisturizer alone (P<0.02).
Human trial · 2011 · 32 people · women aged 25-55 with normal or self-perceived dry facial skin · Investigator-graded facial dryness and softness over 2 weeks. · The comparator is a moisturizer alone.
- Skin effectEfficacy of a moisturizing cream and facial mask for alleviating skin problems associated with medical mask use: A half-face, randomized controlled study
In a half-face randomized controlled study of 64 women, a moisturizing facial cream applied after medical-mask wear improved the treated half-face's skin dryness score by -1.00 and TEWL by -2.95 g/h per cm2 within 10 minutes, versus 0.00 and -0.68 on the untreated half-face (both p<0.001); a cream-plus-mask combination gave larger improvements at 1 hour and later.
Human trial · 2024 · 64 people · healthy women wearing medical masks · Clinician-graded facial dryness score and TEWL shortly after application. · Acute, short-term effects (10 minutes to 1 hour) in a mask-wear setting.
- Skin effectSignificantly Enhanced Improvement in Dryness, Roughness, Fine Lines and Radiance Following Daily Use of a Novel Multi-Weight Hyaluronic Acid Plus Antioxidant Complex-Based Lotion Compared to a Single-Weight HA Plus Ceramide-Based Lotion
In a double-blind comparative study of 70 women with mild-to-moderate facial dryness, a multi-weight hyaluronic acid plus antioxidant lotion produced significantly greater improvements in clinician-graded visible dryness, roughness and fine lines over 8 weeks than a single-weight hyaluronic acid plus ceramide lotion, with improvements visible from week 2.
Human trial · 2024 · 70 people · women aged 25-65 with mild-to-moderate facial dryness and fine lines · Clinician-graded facial dryness, roughness and fine lines over 8 weeks. · Both arms used active moisturisers with SPF30; the study was funded by the product manufacturer.