Clinical evaluation of 40% urea and 12% ammonium lactate in the treatment of xerosis

Kind of evidence: Human trial 2002 · 25 people · people with moderate-to-severe xerosis (18 completed) · PMID 11978141
Measured outcome: Skin effect
Year: 2002
Who was studied: 25 people with moderate-to-severe xerosis (18 completed)
Sample size: 25
Measured outcome: In a randomized, double-blind, bilateral paired trial of 25 people with moderate-to-severe xerosis, 40% urea cream was superior to 12% ammonium lactate lotion at day 14 on skin roughness, fissure reduction, thickness and dryness, with skin desquamation measured instrumentally.
Certainty: Moderate
Who was measured: People with moderate-to-severe xerosis applying 40% urea cream or 12% ammonium lactate for 14 days.
Study limits: A very high 40% urea concentration is a keratolytic treatment.

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