PoreWise One finding · Human trial · 2017
Study title
Clinical efficacy of liposome-encapsulated Aloe vera on melasma treatment during pregnancy
- Kind of evidence
- Human trial 2017 · 180 people · pregnant women with melasma in the second trimester or later (90 per group) · PMID 28139161
- Measured outcome
- Skin effect
- Year
- 2017
- Who was studied
- 180 pregnant women with melasma in the second trimester or later (90 per group)
- Sample size
- 180
- Measured outcome
- In a double-blind randomized trial of 180 pregnant women with melasma in their second trimester or later, 5 weeks of liposome-encapsulated Aloe vera leaf gel extract improved MASI scores by 32% versus 10% with the non-liposomal Aloe vera gel control, with a significant between-group difference in mean MASI after treatment.
- Certainty
- Moderate
- Who was measured
- Melasma Area and Severity Index (MASI) over 5 weeks in pregnant women.
- Study limits
- The comparator is an active Aloe vera gel.
Where it comes from
- Clinical efficacy of liposome-encapsulated Aloe vera on melasma treatment during pregnancy
Published by Journal of Cosmetic and Laser Therapy (Ghafarzadeh M, 2017) · Last checked 2026-11-10
Ingredients it was measured on
Skin concerns studied
Other findings on the same ingredient or concern
- Skin effectMelasma in pregnancy: reduction of its appearance with the use of a broad-spectrum sunscreen
In a placebo-controlled trial in pregnant women, daily application of a broad-spectrum SPF 10 sunscreen to the face from the second trimester through summer significantly reduced the appearance of melasma compared with placebo among the 30 women with good adherence (14 sunscreen, 16 placebo).
Human trial · 1987 · 30 people · pregnant women with good adherence (14 sunscreen / 16 placebo), analysed from a larger enrolled cohort · Appearance of melasma during pregnancy with daily facial sunscreen use. · 30 adherent participants were analysed; SPF 10 is far below current broad-spectrum recommendations; published in 1987 in a Spanish-language journal; the effect is on preventing new melasma.