PoreWise One finding · Official legal text · 1993
Document title
21 CFR 347.10 - Skin protectant active ingredients (US Code of Federal Regulations)
- Kind of evidence
- Official legal text 1993 · Consumers of over-the-counter skin protectant products in the US
- Measured outcome
- Legal limits
- Year
- 1993
- Who was studied
- Consumers of over-the-counter skin protectant products in the US
- Sample size
- Measured outcome
- US regulation lists dimethicone as a permitted active ingredient in over-the-counter skin protectant products, at 1 to 30 percent. That is a legal status in one market, and it puts dimethicone in the same list as petrolatum, glycerin and colloidal oatmeal.
- Certainty
- High
- Who was measured
- Products sold in the US that make a skin-protectant claim, with dimethicone between 1 and 30 percent.
- Study limits
- A monograph entry sets what may be sold and what may be claimed. · 1993 · Consumers of over-the-counter skin protectant products in the US.
Where it comes from
- 21 CFR 347.10 - Skin protectant active ingredients (US Code of Federal Regulations)
Published by US Food and Drug Administration / Office of the Federal Register (eCFR) · Last checked 2026-10-26
Ingredients it was measured on
Skin concerns studied
Other findings on the same ingredient or concern
- Skin effectGlycerol and the skin: holistic approach to its origin and functions
Topical glycerol improves stratum corneum hydration, barrier function and skin mechanical properties. The review also reports reduced irritation response and faster wound healing, and traces the effect to aquaporin-3 transport and to glycerol's own presence in the skin.
Review article · 2008 · Humans in the cited studies, plus animal and in-vitro work on mechanism · Leave-on products. The review discusses both healthy skin and skin with dry or barrier-impaired conditions such as atopic dermatitis. · A narrative review. It compiles mechanisms and results from other studies.
- Skin effectNiacinamide-containing facial moisturizer improves skin barrier and benefits subjects with rosacea
A facial moisturiser containing niacinamide improved stratum corneum barrier function and skin hydration, measured instrumentally, in people with rosacea over four weeks of twice-daily use.
Human trial · 2005 · 50 people · Adults with rosacea · A leave-on facial moisturiser, applied twice daily for four weeks, in adults with rosacea. · The tested article was a finished moisturiser. Fifty participants, one centre, four weeks. The study measured barrier function and hydration.
- Skin effectEvaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study
After facial non-ablative fractional laser treatment, a panthenol mask lowered the erythema and pigmentation indices on days 3, 7 and 14 against a saline dressing, raised stratum corneum moisture, and reduced transepidermal water loss over the same days. Sebum content was also higher in the mask group on days 7 and 14.
Human trial · 2025 · 60 people · Adults recovering from facial non-ablative fractional laser treatment · Skin recovering from 1550 nm and 1927 nm non-ablative fractional laser on the face. Both groups received standard post-procedure care. · The mask also contained madecassoside and bisabolol. It is one trial of 60 people, all recovering from the same procedure, and the published grant list includes L'Oreal Dermatological Beauty China (La Roche-Posay).
- SensitizationPantothenic Acid as an Unexpected Cause of Hypersensitivity to Sensitive or Atopic Skin Care Products - A Narrative Review
Panthenol is treated as non-allergenic, this review argues that frequent exposure, especially on damaged skin, can produce hypersensitivity to it. The likely route is a delayed (type IV) contact reaction; immediate and mixed reactions remain possible. Proposes patch testing with the patient's own product and with panthenol 5% in petrolatum.
Review article · 2026 · People with atopic or damaged skin using panthenol-containing products · People who use panthenol products repeatedly, particularly those with atopic or damaged skin - the group the author says is most exposed. · A single-author narrative review. The mechanism it proposes is stated as likely. Read it as a reason to keep panthenol on the list of possible allergens.