One finding · Human trial · 2020
Study title
A cleanser formulated with Tris (hydroxymethyl) aminomethane and l-arginine significantly improves facial acne in male Thai subjects
- Kind of evidence
- Human trial 2020 · 34 people · Thai men with mild-to-moderate acne · PMID 31347768
- Measured outcome
- Skin effect
- Year
- 2020
- Who was studied
- 34 Thai men with mild-to-moderate acne
- Sample size
- 34
- Measured outcome
- In a 4-week randomized, double-blind controlled trial of 34 men with mild-to-moderate acne, a cleanser formulated with tris(hydroxymethyl)aminomethane and L-arginine significantly reduced the average pore size with keratotic plugs on the cheeks, along with non-inflammatory and inflammatory acne lesions.
- Certainty
- Moderate
- Who was measured
- Men with mild-to-moderate acne using a rinse-off cleanser twice daily for 4 weeks.
- Study limits
- A rinse-off cleanser.
Where it comes from
- A cleanser formulated with Tris (hydroxymethyl) aminomethane and l-arginine significantly improves facial acne in male Thai subjects
Published by Journal of Cosmetic Dermatology (Kumtornrut C, et al.) · Last checked 2026-11-10
Skin concerns studied
Other findings on the same ingredient or concern
- Skin effectThe effect of physically applied alpha hydroxyl acids on the skin pore and comedone
In 23 women, a single application of a 4% alpha-hydroxy acid solution combined with negative-pressure physical action significantly reduced whitehead and blackhead counts at 1, 2 and 4 weeks, and reduced pore area and number at week 1, compared with AHA peeling alone.
Human trial · 2015 · 23 people · healthy women (mean age 30) · Healthy women receiving a single in-clinic application in a randomised split-face design, assessed at 1, 2 and 4 weeks. · The intervention was a single in-clinic chemical peeling plus negative-pressure physical action.
- Skin effectEfficacy and safety of a facial serum and a mask containing salicylic acid and lipohydroxy acid in acne management: A randomized controlled trial
In 83 adults with comedones, a serum containing salicylic acid and lipohydroxy acid significantly improved open comedones on the nose, closed comedones on the face, skin pore density, sebum secretion and skin hydration from baseline after 8 weeks; adding a mask improved closed comedones more than the serum alone (-6.56 vs -5.19, p = 0.022).
Human trial · 2023 · 83 people · adults with comedones (41 serum+mask, 42 serum alone) · Adults in Shanghai with comedones, PIE and PIH, using the serum for 8 weeks. · Both groups used active products; improvements were reported against baseline and between the two active groups. Industry-funded. This is the trial found that counted open and closed comedones separately.
- Skin effectThe clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial
In a randomized, double-blind, placebo-controlled split-face trial of 52 Taiwanese subjects, 4% niacinamide alone significantly reduced instrument-measured pore counts at week 8, and 4% niacinamide with 0.03% kinetin produced persistent significant reductions in pore, spot, wrinkle and evenness counts at weeks 8 and 12.
Human trial · 2007 · 52 people · Taiwanese subjects · Instrument-measured facial pore counts over 8-12 weeks. · The niacinamide-group showed significant pore reduction at week 8; 'pore counts' is an instrument parameter.
- Skin effectEfficacy and safety of a novel anhydrous 0.1% retinal and 10% azelaic acid concentrate for blemish-prone skin: an eight-week randomized prospective split-face, vehicle-controlled study
In an 8-week randomized, vehicle-controlled split-face study of 23 people with blemish-prone skin, an anhydrous 0.1% retinal / 10% azelaic acid concentrate improved the pore parameter by 22.3% versus vehicle (p=0.015) and skin texture by 5.6% versus vehicle (p=0.0016), and reduced surface irregularities by 12.7% versus vehicle (p=0.0053).
Human trial · 2026 · 23 people · participants aged 16-49 (mean 28), Fitzpatrick I-IV, blemish-prone skin · Pore appearance, skin texture and surface irregularities on the face over 8 weeks. · The pore improvement versus baseline was borderline (15.9%, p=0.051); the small sample completed 23 participants; the product is a six-ingredient concentrate; 10% azelaic acid is regulated as an OTC drug in some markets.