Bio-Active Ceramide Moisturizer

Product description

A ceramide-rich moisturizer formulated to support the skin barrier.

Full ingredient list

Kept exactly as the source printed it, including spelling in the original.

1. 1 WATER
2. 2 GLYCERIN
3. 3 BUTYROSPERMUM PARKII BUTTER
4. 4 C12-15 ALKYL BENZOATE
5. 5 PROPANEDIOL
6. 6 POLYSILICONE-11
7. 7 C10-18 TRIGLYCERIDES
8. 8 CAPRYLIC/CAPRIC TRIGLYCERIDE
9. 9 PENTAERYTHRITYL TETRAISOSTEARATE
10. 10 CETEARYL OLIVATE
11. 11 SORBITAN OLIVATE
12. 12 CETYL ALCOHOL
13. 13 PHENOXYETHANOL
14. 14 CERAMIDE NP
15. 15 POLYACRYLATE-13
16. 16 HYDROGENATED POLYISOBUTENE
17. 17 ETHYLHEXYLGLYCERIN
18. 18 POLYGLYCERYL-10 LAURATE
19. 19 ETHYLHEXYL PALMITATE
20. 20 LAURETH-12
21. 21 SORBITAN ISOSTEARATE
22. 22 HDI/TRIMETHYLOL HEXYLLACTONE CROSSPOLYMER
23. 23 POLYMETHYLSILSESQUIOXANE
24. 24 CITRIC ACID
25. 25 SODIUM HYDROXIDE

Water (Aqua/Eau), Glycerin, Butyrospermum Parkii (Shea) Butter, C12-15 Alkyl Benzoate, Propanediol, Polysilicone-11, C10-18 Triglycerides, Caprylic/Capric Triglyceride, Pentaerythrityl Tetraisostearate, Cetearyl Olivate, Sorbitan Olivate, Cetyl Alcohol, Phenoxyethanol, Ceramide NP, Polyacrylate-13, Hydrogenated Polyisobutene, Ethylhexylglycerin, Polyglyceryl-10 Laurate, Ethylhexyl Palmitate, Laureth-12, Sorbitan Isostearate, HDI/Trimethylol Hexyllactone Crosspolymer, Polymethylsilsesquioxane, Citric Acid, Sodium Hydroxide

Ingredient analysis

CERAMIDE NP · Barrier lipids · GLYCERIN · Humectants · BUTYROSPERMUM PARKII BUTTER · Emollients

Evidence

• Skin effect Human trial Certainty: Moderate Primary source

  In 88 women with sensitive skin, a face cream containing Centella asiatica leaf extract, ceramide NP and panthenol lowered the SS-10 symptom score by 66% at week 2 and 76% at week 4, with irritation, tautness, itching and redness all significantly reduced.

  Who it applies to: Chinese women with sensitive skin applying the cream to the whole face, followed up at day 2, weeks 1, 2 and 4.

  Study limits: Observational and self-controlled.

  Source:The Effectiveness and Safety of a Skin Care Product With Centella asiatica Leaf Extract, Ceramide NP, and Panthenol in Subjects With Sensitive Skin: A Prospective, Observational Study
• Skin effect Human trial Certainty: Moderate Primary source

  In a randomized, double-blind, vehicle-controlled split-body trial of 50 people with sensitive skin, an emollient containing Ceramide NP C15 significantly reduced transepidermal water loss in participants with an impaired skin barrier over 6 weeks.

  Who it applies to: People with sensitive skin applying the emollient in a split-body design for 6 weeks; the barrier improvement was clearest in those whose barrier was already impaired.

  Study limits: Exploratory; both the ceramide formulation and the vehicle improved subjective symptoms, and the significant TEWL reduction was seen specifically in the impaired-barrier subgroup.

  Source:Monocentric, Vehicle-Controlled, Double-Blind Study to Assess the Short- and Long-Term Effects of a Ceramide NP C15-Containing Emollient on the Skin Microbiome and the Skin Barrier Function in Sensitive Skin
• Skin effect Human trial Certainty: Moderate Primary source

  In adults with mild-to-moderate xerosis (senile xerosis), a cream containing ceramides 1, 3, 6-II improved stratum corneum hydration, transepidermal water loss and skin pH more than a hydrophilic cream, measured at 24 hours and after 28 days of twice-daily use.

  Who it applies to: Leave-on moisturizers for dry skin. The study enrolled adults with mild-to-moderate xerosis.

  Study limits: Small single-site study (24 participants), split-site comparison on the shins, 28 days. It shows the tested formula outperformed a basic hydrophilic cream on measured skin parameters.

  Source:The 24-hr, 28-day, and 7-day post-moisturizing efficacy of ceramides 1, 3, 6-II containing moisturizing cream compared with hydrophilic cream on skin dryness and barrier disruption in senile xerosis treatment
• Skin effect Human trial Certainty: Moderate Primary source

  In 40 people with mild-to-moderate acne all using topical benzoyl peroxide plus adapalene, a moisturiser with ceramides and niacinamide significantly improved non-inflammatory, inflammatory and total acne lesions on that side of the face versus a hydrophilic cream after 8 weeks, and decreased cutaneous irritation.

  Who it applies to: People on topical anti-acne medication who add a moisturiser alongside treatment, in a split-face, double-blind, randomized design for 8 weeks.

  Study limits: All participants used prescription/OTC anti-acne drugs (5% benzoyl peroxide + 0.1% adapalene). TEWL, hydration, sebum, pH and other biophysical measures stayed close between the two creams. This is adjunctive care.

  Source:Efficacy of ceramides and niacinamide-containing moisturizer versus hydrophilic cream in combination with topical anti-acne treatment in mild to moderate acne vulgaris: A split face, double-blinded, randomized controlled trial
• Skin effect Brand claim Certainty: High Public database

  Ceramides, cholesterol and fatty acids are the lipids that make up the skin barrier; formulations add them to replenish it.

  Who it applies to: Barrier function generally; the ratio between the three lipid classes matters in the literature.

  Study limits: Finding · CERAMIDE NP · Ceramide AP · Ceramide EOP

  Source:The Ceramides Difference (CeraVe)CosIng — European Commission cosmetic ingredient database
• Skin effect Human trial Certainty: Moderate Primary source

  In a randomized, double-blind, four-arm crossover study of 51 healthy volunteers with dry skin, an emollient containing glycerol and petrolatum raised corneometry-measured skin moisture significantly above its vehicle (P < 0.0001) over 12 hours. The authors attributed the hydration gain to the glycerol component and the lower water loss to the petrolatum component.

  Who it applies to: Corneometry (skin moisture) and transepidermal water loss over 12 hours after one application.

  Study limits: Measured on the forearms. The significant hydration result comes from the full emollient containing both glycerol and petrolatum.

  Source:Combined effects of glycerol and petrolatum in an emollient cream: A randomized, double-blind, crossover study in healthy volunteers with dry skin
• Skin effect Review article Certainty: Moderate Primary source

  Topical glycerol improves stratum corneum hydration, barrier function and skin mechanical properties. The review also reports reduced irritation response and faster wound healing, and traces the effect to aquaporin-3 transport and to glycerol's own presence in the skin.

  Who it applies to: Leave-on products. The review discusses both healthy skin and skin with dry or barrier-impaired conditions such as atopic dermatitis.

  Study limits: A narrative review. It compiles mechanisms and results from other studies.

  Source:Glycerol and the skin: holistic approach to its origin and functions
• Skin effect Official ingredient listing Certainty: High Public database

  Glycerin is classified as a humectant in cosmetic ingredient databases: its role in a formula is to hold water.

  Who it applies to: Cosmetic formulas generally. · Ingredient database · GLYCERIN

  Study limits: Skin effect of to the stratum corneum comes from a separate review of the literature. · Ingredient database · GLYCERIN

  Source:PubChemCosIng — European Commission cosmetic ingredient database
• Pore clogging Animal study Certainty: Low Primary source

  In the rabbit ear-canal assay, the nine materials graded positive were eight esters (isopropyl palmitate, isopropyl myristate, butyl stearate, isopropyl isostearate, decyl oleate, isostearyl neopentanoate, isocetyl stearate, myristyl myristate) and cocoa butter.

  Who it applies to: Materials applied to the rabbit ear canal as raw ingredients.

  Study limits: An animal assay. The rabbit ear canal reacts more readily than human skin. The abstract names the positive group.

  Source:Comedogenicity in rabbit: some cosmetic ingredients/vehicles
• Legal limits Official legal text Certainty: High Primary source

  The EU Scientific Committee on Consumer Safety concluded in 2016 that 2-phenoxyethanol is safe as a preservative at a maximum of 1.0%, which is the limit already set in Annex V/29 of the EU Cosmetics Regulation. It estimated a margin of safety of about 50 for children.

  Who it applies to: Phenoxyethanol used as a preservative in cosmetic products, at or below 1.0%.

  Study limits: The dossier behind the conclusion was submitted by Cosmetics Europe, the industry association, and the committee lowered the default toxicokinetic factor from 4.0 to 1.0 on its way to the 1.0% conclusion. The final opinion kept 1.0%.

  Source:Opinion of the Scientific Committee on Consumer Safety (SCCS) - Final version of the opinion on Phenoxyethanol in cosmetic products

Related skin concerns

Skin concerns with evidence for ingredients on this list.

Formula history

1 version of this formula on record.

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