PoreWise One finding · Human trial · 2026
Study title
Shake-Induced Temporary Ion-Pairing Between Lecithin and Glycolic Acid for Enhanced Exfoliation in a Novel Biphasic Serum: Comparative Ex Vivo and in Vivo Randomised Studies
- Kind of evidence
- Human trial 2026 · 37 people · participants in a split-face study · PMID 41987370
- Measured outcome
- Skin effect
- Year
- 2026
- Who was studied
- 37 participants in a split-face study
- Sample size
- 37
- Measured outcome
- In a 2-week double-blind split-face study of 37 participants, a biphasic serum with 10% glycolic acid delivered 45.52% greater exfoliation (p<0.001) and improved skin brightness, texture and hydration versus the comparison side.
- Certainty
- Moderate
- Who was measured
- Healthy participants using a 10% glycolic acid biphasic serum on one side of the face for 2 weeks.
- Study limits
- Short duration (2 weeks) and a single product formulation; the study measured exfoliation and cosmetic parameters.
Where it comes from
- Shake-Induced Temporary Ion-Pairing Between Lecithin and Glycolic Acid for Enhanced Exfoliation in a Novel Biphasic Serum: Comparative Ex Vivo and in Vivo Randomised Studies
Published by Skin Research and Technology (Kwon KC, Kim MJ) · Last checked 2026-10-29
Ingredients it was measured on
Skin concerns studied
Other findings on the same ingredient or concern
- Skin effectThe effect of physically applied alpha hydroxyl acids on the skin pore and comedone
In 23 women, a single application of a 4% alpha-hydroxy acid solution combined with negative-pressure physical action significantly reduced whitehead and blackhead counts at 1, 2 and 4 weeks, and reduced pore area and number at week 1, compared with AHA peeling alone.
Human trial · 2015 · 23 people · healthy women (mean age 30) · Healthy women receiving a single in-clinic application in a randomised split-face design, assessed at 1, 2 and 4 weeks. · The intervention was a single in-clinic chemical peeling plus negative-pressure physical action.
- Skin effectComparative study of buffered 50% glycolic acid (pH 3.0) + 0.5% salicylic acid solution vs Jessner's solution in patients with acne vulgaris
In a prospective, randomized, evaluator-blind, split-face trial of 20 patients with acne vulgaris, two 50% glycolic acid + 0.5% salicylic acid peels significantly reduced total lesion count (P<0.001) and produced fewer side effects than Jessner's solution.
Human trial · 2018 · 20 people · patients with acne vulgaris · Patients with acne vulgaris receiving two 50% glycolic acid + 0.5% salicylic acid peels 2 weeks apart (one side vs Jessner's solution on the other). · Small sample (20) and a combination peel (glycolic + salicylic acid); this is a procedural peel.
- Skin effectAssessing the Value of Botanical Anti-Inflammatory Agents in an OTC Acne Treatment Regimen
In a 12-week randomized trial of 80 subjects aged 12 and over with mild-to-moderate acne, a botanical anti-inflammatory OTC skincare regimen produced significantly lower closed-comedone counts than a benzoyl peroxide comparator at week 4 (P<0.001) and week 12 (P=0.006), with fewer inflammatory lesions at week 4 (P=0.016).
Human trial · 2015 · 80 people · subjects aged 12+ with mild-to-moderate acne · Closed-comedone and inflammatory lesion counts over 12 weeks. · The comparator is an active benzoyl peroxide regimen.
- Skin effectEvaluation of anti-wrinkle effects of a novel cosmetic containing niacinamide
In a randomized, placebo-controlled split-face study of 30 healthy Japanese women, a cosmetic containing 4% niacinamide reduced the skin-surface average roughness (Ra) value significantly more than the niacinamide-free control site after 8 weeks (P<0.05).
Human trial · 2008 · 30 people · healthy Japanese women with wrinkles in the eye areas · Skin-surface roughness measured by replica profilometry (Ra). · Measured at the eye area on a photoaged/wrinkle cohort; the endpoint is surface roughness.
- Skin effectEfficacy and safety of a novel anhydrous 0.1% retinal and 10% azelaic acid concentrate for blemish-prone skin: an eight-week randomized prospective split-face, vehicle-controlled study
In an 8-week randomized, vehicle-controlled split-face study of 23 people with blemish-prone skin, an anhydrous 0.1% retinal / 10% azelaic acid concentrate improved the pore parameter by 22.3% versus vehicle (p=0.015) and skin texture by 5.6% versus vehicle (p=0.0016), and reduced surface irregularities by 12.7% versus vehicle (p=0.0053).
Human trial · 2026 · 23 people · participants aged 16-49 (mean 28), Fitzpatrick I-IV, blemish-prone skin · Pore appearance, skin texture and surface irregularities on the face over 8 weeks. · The pore improvement versus baseline was borderline (15.9%, p=0.051); the small sample completed 23 participants; the product is a six-ingredient concentrate; 10% azelaic acid is regulated as an OTC drug in some markets.