CeraVe SA Cream for Rough & Bumpy Skin vs CeraVe Moisturizing Cream

In 83 adults with comedones, a serum containing salicylic acid and lipohydroxy acid significantly improved open comedones on the nose, closed comedones on the face, skin pore density, sebum secretion and skin hydration from baseline after 8 weeks; adding a mask improved closed comedones more than the serum alone (-6.56 vs -5.19, p = 0.022).

Human trial · 2023 · 83 people · adults with comedones (41 serum+mask, 42 serum alone) · Adults in Shanghai with comedones, PIE and PIH, using the serum for 8 weeks. · Both groups used active products; improvements were reported against baseline and between the two active groups. Industry-funded. This is the trial found that counted open and closed comedones separately.

PMID 36999489

The 2024 American Academy of Dermatology acne guideline lists topical salicylic acid as a conditional recommendation. Strong recommendations in the same guideline go to benzoyl peroxide, topical retinoids, topical antibiotics and oral doxycycline.

Clinical guideline · 2024 · Acne vulgaris in people aged nine and older, as covered by the guideline's scope.

PMID 38300170

In a randomized, placebo-controlled split-face study of 30 healthy Japanese women, a cosmetic containing 4% niacinamide reduced the skin-surface average roughness (Ra) value significantly more than the niacinamide-free control site after 8 weeks (P<0.05).

Human trial · 2008 · 30 people · healthy Japanese women with wrinkles in the eye areas · Skin-surface roughness measured by replica profilometry (Ra). · Measured at the eye area on a photoaged/wrinkle cohort; the endpoint is surface roughness.

PMID 19017042

In 20 people with Fitzpatrick skin types IV-V, a broad-spectrum sunscreen containing sclareolide and niacinamide significantly prevented experimentally induced post-inflammatory hyperpigmentation: in stripped, exposed zones the protected skin improved by +5.96 ITA degrees versus -9.88 in unprotected skin (net protection about 16 ITA degrees, p < 0.001).

Human trial · 2026 · 20 people · participants with Fitzpatrick skin types IV-V · People with darker skin phototypes (IV-V) prone to post-inflammatory hyperpigmentation, applying the sunscreen daily for 20 days under UV and visible-light exposure. · Small sample (20), within-subject controlled model of experimentally induced pigmentation; the abstract calls for comparative studies with and; industry involvement.

PMID 41240206

All five 0.1% hyaluronic acid creams tested, from 50 kDa to 2000 kDa, raised skin hydration and overall elasticity above the vehicle cream applied to the other eye at 60 days.

Human trial · 2011 · 76 people · Women aged 30-60 with periocular wrinkles · 0.1% hyaluronic acid creams applied twice daily for 60 days to the eye area of women aged 30-60 with periocular wrinkles. · Sixty days, and the vehicle sat on the fellow eye. Hydration and elasticity were read by instruments. The volunteers were women aged 30-60 with eye-area wrinkles.

PMID 22052267

Hyaluronic acid and its salt bind water at the skin surface, giving a plumper look immediately after application.

Brand claim · Leave-on hydrating products. · The effect is largely surface and temporary. In dry air a humectant. · Finding · Sodium hyaluronate · Hydrolyzed hyaluronic acid