PoreWise La Roche-Posay Hyalu B5 Suractivated Serum vs The Ordinary Hyaluronic Acid 2% + B5
12 shared ingredients · La Roche-Posay Hyalu B5 Suractivated Serum 20 ingredients · The Ordinary Hyaluronic Acid 2% + B5 11 ingredients
Where the two ingredient lists differ
La Roche-Posay Hyalu B5 Suractivated Serum · 20
- Denatured Alcohol
- PROPYLENE GLYCOL
- DIMETHICONE
- PEG-6 CAPRYLIC/CAPRIC GLYCERIDES
- ALPINIA GALANGA LEAF EXTRACT
- CALCIUM CHLORIDE
- GLYCERYL ISOSTEARATE
- MADECASSOSIDE
- PPG-6-DECYLTETRADECETH-30
- SODIUM ACETYLATED HYALURONATE
- ALGIN
- ADENOSINE
- AMMONIUM POLYACRYLOYLDIMETHYL TAURATE
- HYDROXYACETOPHENONE
- CAPRYLIC/CAPRIC TRIGLYCERIDE
- ACETYL GLUCOSAMINE
- Xanthan Gum
- BUTYLENE GLYCOL
- 1,2-HEXANEDIOL
- Parfum
What has been studied about what both contain
- GLYCERIN Skin effectCombined effects of glycerol and petrolatum in an emollient cream: A randomized, double-blind, crossover study in healthy volunteers with dry skin
In a randomized, double-blind, four-arm crossover study of 51 healthy volunteers with dry skin, an emollient containing glycerol and petrolatum raised corneometry-measured skin moisture significantly above its vehicle (P < 0.0001) over 12 hours. The authors attributed the hydration gain to the glycerol component and the lower water loss to the petrolatum component.
Human trial · 2020 · 51 people · healthy volunteers with dry skin (Kligman score 2 or 3) · Corneometry (skin moisture) and transepidermal water loss over 12 hours after one application. · Measured on the forearms. The significant hydration result comes from the full emollient containing both glycerol and petrolatum.
- GLYCERIN Skin effectGlycerol and the skin: holistic approach to its origin and functions
Topical glycerol improves stratum corneum hydration, barrier function and skin mechanical properties. The review also reports reduced irritation response and faster wound healing, and traces the effect to aquaporin-3 transport and to glycerol's own presence in the skin.
Review article · 2008 · Humans in the cited studies, plus animal and in-vitro work on mechanism · Leave-on products. The review discusses both healthy skin and skin with dry or barrier-impaired conditions such as atopic dermatitis. · A narrative review. It compiles mechanisms and results from other studies.
- PANTHENOL Skin effectThe Effectiveness and Safety of a Skin Care Product With Centella asiatica Leaf Extract, Ceramide NP, and Panthenol in Subjects With Sensitive Skin: A Prospective, Observational Study
In 88 women with sensitive skin, a face cream containing Centella asiatica leaf extract, ceramide NP and panthenol lowered the SS-10 symptom score by 66% at week 2 and 76% at week 4, with irritation, tautness, itching and redness all significantly reduced.
Human trial · 2025 · 88 people · women with sensitive skin · Chinese women with sensitive skin applying the cream to the whole face, followed up at day 2, weeks 1, 2 and 4. · Observational and self-controlled.
- PANTHENOL Skin effectA cream containing linoleic acid, 5% dexpanthenol and ceramide in the treatment of atopic dermatitis
In 38 children with atopic dermatitis, a cream containing linoleic acid, 5% dexpanthenol and ceramide improved SCORAD significantly more than a 5% urea cream after 4 weeks (P = 0.043); both groups improved from baseline.
Human trial · 2024 · 38 people · children with atopic dermatitis (37 completed) · Children with mild-to-moderate atopic dermatitis applying the cream twice daily for 4 weeks in a randomised, double-blind, bilateral paired design. · Both interventions were non-prescription moisturisers: this is emollient / basic skin care. Small sample (37 completed); stratum corneum hydration and time to remission stayed close between groups.
- PANTHENOL Skin effectEfficacy and safety of a cream containing panthenol, prebiotics, and probiotic lysate for improving sensitive skin symptoms
In 110 people with facial sensitive skin, a cream containing panthenol used twice daily for 28 days significantly increased stratum corneum moisture and reduced erythema index, redness (a* value) and transepidermal water loss.
Human trial · 2024 · 110 people · people with facial sensitive skin · People with facial sensitive skin applying the cream twice daily for 28 days. · Panthenol was combined with prebiotics and a probiotic lysate.
The situations those studies looked at
What to watch for
La Roche-Posay Hyalu B5 Suractivated Serum
- PANTHENOL SensitizationPantothenic Acid as an Unexpected Cause of Hypersensitivity to Sensitive or Atopic Skin Care Products - A Narrative Review
Panthenol is treated as non-allergenic, this review argues that frequent exposure, especially on damaged skin, can produce hypersensitivity to it. The likely route is a delayed (type IV) contact reaction; immediate and mixed reactions remain possible. Proposes patch testing with the patient's own product and with panthenol 5% in petrolatum.
Review article · 2026 · People with atopic or damaged skin using panthenol-containing products · People who use panthenol products repeatedly, particularly those with atopic or damaged skin - the group the author says is most exposed. · A single-author narrative review. The mechanism it proposes is stated as likely. Read it as a reason to keep panthenol on the list of possible allergens.
- TOCOPHEROL SensitizationThe effects of topical vitamin E on the cosmetic appearance of scars
In the same split-scar trial, 33% of the participants developed contact dermatitis to the vitamin E ointment.
Human trial · 1999 · 15 people · Adults after surgical removal of skin cancer · Vitamin E in a petrolatum-based ointment applied to healing surgical wounds, twice daily for four weeks. · Small trial (15 people) with a single product.
The Ordinary Hyaluronic Acid 2% + B5
- PANTHENOL SensitizationPantothenic Acid as an Unexpected Cause of Hypersensitivity to Sensitive or Atopic Skin Care Products - A Narrative Review
Panthenol is treated as non-allergenic, this review argues that frequent exposure, especially on damaged skin, can produce hypersensitivity to it. The likely route is a delayed (type IV) contact reaction; immediate and mixed reactions remain possible. Proposes patch testing with the patient's own product and with panthenol 5% in petrolatum.
Review article · 2026 · People with atopic or damaged skin using panthenol-containing products · People who use panthenol products repeatedly, particularly those with atopic or damaged skin - the group the author says is most exposed. · A single-author narrative review. The mechanism it proposes is stated as likely. Read it as a reason to keep panthenol on the list of possible allergens.
- TOCOPHEROL SensitizationThe effects of topical vitamin E on the cosmetic appearance of scars
In the same split-scar trial, 33% of the participants developed contact dermatitis to the vitamin E ointment.
Human trial · 1999 · 15 people · Adults after surgical removal of skin cancer · Vitamin E in a petrolatum-based ointment applied to healing surgical wounds, twice daily for four weeks. · Small trial (15 people) with a single product.
Both ingredient lists and where they came from
Ingredient list from： Hyalu B5 Suractivated Serum — brand product page (Singapore), full ingredient list · last checked 2026-10-30
Ingredient list from： Hyaluronic Acid 2% + B5 — brand product page · last checked 2026-10-30