The Ordinary Hyaluronic Acid 2% + B5 vs The Ordinary Niacinamide 10% + Zinc 1%

All five 0.1% hyaluronic acid creams tested, from 50 kDa to 2000 kDa, raised skin hydration and overall elasticity above the vehicle cream applied to the other eye at 60 days.

Human trial · 2011 · 76 people · Women aged 30-60 with periocular wrinkles · 0.1% hyaluronic acid creams applied twice daily for 60 days to the eye area of women aged 30-60 with periocular wrinkles. · Sixty days, and the vehicle sat on the fellow eye. Hydration and elasticity were read by instruments. The volunteers were women aged 30-60 with eye-area wrinkles.

PMID 22052267

In 88 women with sensitive skin, a face cream containing Centella asiatica leaf extract, ceramide NP and panthenol lowered the SS-10 symptom score by 66% at week 2 and 76% at week 4, with irritation, tautness, itching and redness all significantly reduced.

Human trial · 2025 · 88 people · women with sensitive skin · Chinese women with sensitive skin applying the cream to the whole face, followed up at day 2, weeks 1, 2 and 4. · Observational and self-controlled.

PMID 40682399

In 38 children with atopic dermatitis, a cream containing linoleic acid, 5% dexpanthenol and ceramide improved SCORAD significantly more than a 5% urea cream after 4 weeks (P = 0.043); both groups improved from baseline.

Human trial · 2024 · 38 people · children with atopic dermatitis (37 completed) · Children with mild-to-moderate atopic dermatitis applying the cream twice daily for 4 weeks in a randomised, double-blind, bilateral paired design. · Both interventions were non-prescription moisturisers: this is emollient / basic skin care. Small sample (37 completed); stratum corneum hydration and time to remission stayed close between groups.

PMID 33865303

In 110 people with facial sensitive skin, a cream containing panthenol used twice daily for 28 days significantly increased stratum corneum moisture and reduced erythema index, redness (a* value) and transepidermal water loss.

Human trial · 2024 · 110 people · people with facial sensitive skin · People with facial sensitive skin applying the cream twice daily for 28 days. · Panthenol was combined with prebiotics and a probiotic lysate.

PMID 38186043

In a randomized, placebo-controlled split-face study of 30 healthy Japanese women, a cosmetic containing 4% niacinamide reduced the skin-surface average roughness (Ra) value significantly more than the niacinamide-free control site after 8 weeks (P<0.05).

Human trial · 2008 · 30 people · healthy Japanese women with wrinkles in the eye areas · Skin-surface roughness measured by replica profilometry (Ra). · Measured at the eye area on a photoaged/wrinkle cohort; the endpoint is surface roughness.

PMID 19017042

In 20 people with Fitzpatrick skin types IV-V, a broad-spectrum sunscreen containing sclareolide and niacinamide significantly prevented experimentally induced post-inflammatory hyperpigmentation: in stripped, exposed zones the protected skin improved by +5.96 ITA degrees versus -9.88 in unprotected skin (net protection about 16 ITA degrees, p < 0.001).

Human trial · 2026 · 20 people · participants with Fitzpatrick skin types IV-V · People with darker skin phototypes (IV-V) prone to post-inflammatory hyperpigmentation, applying the sunscreen daily for 20 days under UV and visible-light exposure. · Small sample (20), within-subject controlled model of experimentally induced pigmentation; the abstract calls for comparative studies with and; industry involvement.

PMID 41240206

In 72 women with visible signs of ageing, a niacinamide-containing biomimetic lamellar cream significantly improved the Cutometer R5 elasticity parameter, wrinkle score, TEWL and corneometer values over 4 weeks compared against the untreated side.

Human trial · 2019 · 72 people · women with visible signs of ageing (Study 2) · Women with visible signs of ageing, applying the cream twice daily for 4 weeks. · Grading of high-resolution images failed to detect improvements in skin texture; proof-of-concept studies.

PMID 30414275

In 91 women with melasma, a skincare routine containing vitamin B3 (niacinamide) and 2-mercaptonicotinyl glycine significantly reduced MASI after 3 months, with roughly 38-41% reduction by 6 months.

Human trial · 2025 · 91 people · women with melasma · Women aged about 44 with melasma, phototypes III-IV, using the routine twice daily with daily SPF50+ sunscreen. · A clinically relevant difference favoured Kligman's triple combination in the first 3 months; industry-funded; skin radiance and fine wrinkles also improved.

PMID 41036635